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Published on: October 10, 2012
Traditional Fermented Multi-Grain Supernatant (Ogi-baba Omidun) Restores Hypothalamic-Pituitary-Testicular Axis
Kelechi Favour Chinyere1,2, Adeshina Oloruntoba Adekeye2, Victor Akinmola1,2
1Stress & Neuroimmunology Group, Department of Human Anatomy, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, P.M.B. 5454, Ado-Ekiti, Ekiti, Nigeria.
Insights
This study shows that Ogi-baba Omidun (MGS) and its postbiotics (PSB) can help juvenile rats with PTSD and neuroinflammation. These natural compounds improved anxiety, sexual function, and reproductive hormone levels.
Area of Science:
- Neuroendocrinology
- Immunology
- Pharmacology
Background:
- Juvenile PTSD combined with neuroinflammation severely impacts neuroendocrine and reproductive development.
- Existing treatments for this comorbidity have limitations.
Purpose of the Study:
- To evaluate the therapeutic potential of a traditional fermented multi-grain supernatant (Ogi-baba Omidun; MGS) and its postbiotics (PSB).
- To investigate their effects on a juvenile rat model of PTSD-neuroinflammation comorbidity.
Main Methods:
- PTSD-neuroinflammation comorbidity induced via single prolonged stress and lipopolysaccharide exposure in juvenile rats.
- Administration of MGS and PSB.
- Behavioral tests, hormonal assays, oxidative stress marker analysis, inflammatory signaling assessment (NF-κB, IL-10), and histological/immunofluorescence analyses.
Main Results:
- MGS and PSB significantly reduced anxiety-like behavior and partially restored sexual performance, testosterone, and luteinizing hormone levels.
- Both preparations decreased oxidative stress and pro-inflammatory NF-κB signaling while increasing anti-inflammatory IL-10.
- Neuroendocrine cytoarchitecture was partially preserved, and autophagosome accumulation was reduced.
Conclusions:
- Ogi-baba Omidun (MGS) and its postbiotics (PSB) demonstrate multi-target protective effects against combined traumatic stress and immune activation.
- These findings support the translational potential of MGS as an accessible, gut-mediated intervention for juvenile reproductive axis protection.
Abstract:
Juvenile post-traumatic stress disorder (PTSD) compounded by systemic neuroinflammation poses a significant threat to neuroendocrine and reproductive development. This study evaluated the therapeutic potential of a traditional fermented multi-grain supernatant (Ogi-baba Omidun; MGS) and its postbiotics (PSB) in a juvenile rat model of PTSD-neuroinflammation comorbidity induced by single prolonged stress combined with lipopolysaccharide exposure. MGS and PSB significantly ameliorated anxiety-like behaviour and partially restored sexual performance, testicular testosterone, and luteinising hormone levels. Both preparations reduced oxidative stress markers and pro-inflammatory NF-κB signalling and increased anti-inflammatory IL-10 across the hypothalamic-pituitary-testicular axis. Histological and immunofluorescence analyses revealed partial preservation of neuroendocrine cytoarchitecture and attenuation of LC3B-II-associated autophagosome accumulation. These findings indicate that Ogi-baba Omidun exerts multi-target protective effects against the combined impact of traumatic stress and immune activation on the juvenile reproductive axis, supporting its translational potential as an accessible gut-mediated intervention.
