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Published on: May 30, 2025
Association between inflammatory burden index and erectile dysfunction: a retrospective case-control study.
Ayhan Arslan1, Erdal Benli2, Ahmet Yüce2
1Department of Urology, Ordu University Faculty of Medicine, Ordu, Türkiye. ayhanarslan128@gmail.com.
BMC Urology
|June 4, 2026
Summary
The Inflammatory Burden Index (IBI) was higher in men with erectile dysfunction (ED), but it is not an independent predictor. This marker may reflect inflammation associated with ED but has limited clinical utility for diagnosis.
Area of Science:
- Urology
- Cardiovascular Disease
- Inflammation Research
Background:
- Erectile dysfunction (ED) is a vascular condition linked to systemic inflammation and endothelial dysfunction.
- Inflammatory markers are increasingly recognized for their role in ED pathogenesis.
- The Inflammatory Burden Index (IBI), combining C-reactive protein (CRP) and neutrophil-lymphocyte ratio (NLR), warrants investigation in ED.
Purpose of the Study:
- To evaluate the relationship between the Inflammatory Burden Index (IBI) and erectile dysfunction (ED).
- To assess the diagnostic performance of IBI for identifying ED.
Main Methods:
- Retrospective study of 126 ED patients and 128 controls.
- Erectile function assessed via the International Index of Erectile Function-5 (IIEF-5).
- IBI calculated as CRP × NLR; diagnostic performance analyzed using ROC and logistic regression.
Main Results:
- IBI values were significantly higher in the ED group (median 3.31 vs. 0.91, p < 0.001).
- IBI showed modest discriminatory ability for ED (AUC = 0.754).
- Diabetes mellitus and cardiovascular disease were independent predictors of ED; IBI was not.
Conclusions:
- Elevated IBI in ED patients suggests a link to systemic inflammation.
- IBI's limited discriminatory power and lack of independent predictive value restrict its clinical utility as a standalone marker.
- Further research may explore IBI's role in conjunction with other markers.
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