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Updated: Jun 6, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Selectfluor-Mediated C(sp3)-H Phenoxylation/Cyclization toward Seven-Membered S,O-Heterocycles
Long Liu1, Yuting Pang1, Yue Zhang1
1Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710127, China.
None:
An intramolecular α-C(sp3)-H phenoxylative cyclization of thioethers is developed using phenols as intramolecular nucleophiles and Selectfluor as a mild oxidant, thereby efficiently constructing seven-membered S,O-heterocyclic scaffolds with high efficiency and excellent functional group tolerance. This phenoxy-Pummerer transformation expands the tool box for α-C(sp3)-H functionalization of thioethers, which provides a new paradigm for incorporating oxidation-sensitive nucleophiles under mild conditions.
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