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Updated: Jun 6, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Feedback as a key process in effective integrated knowledge translation
Madeline Dougherty1, Jasminder Bhatti1, Sara Dalo2
1School of Health Studies, Faculty of Health Science, Western University, London, ON, Canada.
Introduction:
Effective feedback can enhance integrated knowledge translation (iKT); it can lead to more successful implementation efforts and support other key implementation mechanisms (such as provider empowerment and readiness to implement). However, there is limited consensus in the literature on how to deliver feedback effectively within iKT contexts specifically, highlighting the need to better understand these practices in real-world implementation settings.
Objective:
The objective of this study was to illustrate how feedback within an iKT approach can support implementation of a chronic disease management (CDM) program in primary care through a case study.
Methods:
For over a decade, we have studied the progressive implementation (scale and spread) of a chronic disease management (CDM) program in primary care. Through our empirical work, we developed a framework to support progressive implementation, spread, and sustainability of CDM programs. Our framework has ten mechanisms across three implementation phases (pre-implementation, implementation, and sustainability). An essential process that crosses all phases is feedback. Using a case study approach, we examine how feedback functioned throughout our decade-long engagement with this CDM program implementation.
Postimplementation Results:
In this paper, we describe the function and process of feedback as core to successful iKT within the context of CDM. We conceptualize feedback as iKT scaffolding that bolsters the mechanisms required for effective implementation, enhances the likelihood of success, and supports sustainability and spread. We emphasize the importance of relationships in reflective and iterative feedback combined with stakeholder engagement, and add to the literature by providing guidance on the effective use of feedback with and among knowledge user partners.
Key Health Care Practice And Health Care Outcomes:
iKT involves collaboration between researchers and knowledge-users and improvements to these partnerships are necessary to improve research dissemination and program implementation. Feedback can be used to improve iKT partnerships by increasing communication between partners. We describe a successful iKT partnership that developed a framework to support progressive implementation of CDM programs. Through this partnership, we highlight the role of feedback. We also provide examples of feedback for others to use within their iKT partnerships from our experience and the literature. We add to the literature by providing this guidance and emphasizing the role of effective feedback to successful iKT partnerships.
Spanish Abstract:
http://links.lww.com/IJEBH/A610.
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