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Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Published on: April 10, 2018

A method to screen for meiotic drive using embryonic markers.

Benjamin K McCormick¹, Daniel A Barbash¹

¹Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853.

Biorxiv : the Preprint Server for Biology

|June 5, 2026

Summary

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Meiotic drivers, selfish genetic elements, can spread even if harmful. This study introduces a new method to detect these drivers in fruit fly embryos before fitness effects mask their transmission.

Area of Science:

Evolutionary Biology
Genetics

Background:

Meiotic drivers are genetic elements that bias their own inheritance during gamete formation.
These drivers can spread in populations despite potentially reducing overall host fitness, leading to co-evolutionary conflicts.
Understanding meiotic drive is crucial for explaining rapid evolution of reproductive systems and genomes.

Purpose of the Study:

To develop and validate a novel method for detecting meiotic drivers.
To overcome challenges in distinguishing meiotic drive from viability effects.
To enable systematic screening of meiotic drivers in wild-derived populations.

Main Methods:

Utilized fluorescent markers in wild-derived *Drosophila melanogaster* embryos.
Implemented a technique to induce embryonic arrest at a standardized developmental stage.

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Last Updated: Jun 6, 2026

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Published on: April 10, 2018

Mouse Oocyte Microinjection, Maturation and Ploidy Assessment

Mouse Oocyte Microinjection, Maturation and Ploidy Assessment

Published on: July 23, 2011

Application of Mouse Parthenogenetic Haploid Embryonic Stem Cells as a Substitute of Sperm

Application of Mouse Parthenogenetic Haploid Embryonic Stem Cells as a Substitute of Sperm

Published on: November 19, 2020

Quantified allele transmission by comparing wild-derived alleles to fluorescently marked homologs in early embryos.

Main Results:

Successfully demonstrated proof-of-concept for the developed driver detection approach.
Identified potential meiotic drivers by observing skewed allele transmission in early embryos.
Established a method to detect drive before significant fitness differences manifest.

Conclusions:

The presented method offers a robust approach for detecting meiotic drivers at the embryonic stage.
This technique facilitates the study of meiotic drive dynamics and its evolutionary consequences.
Future improvements can enhance the scope and accuracy of driver detection.