Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Organization of the Brain01:30

Organization of the Brain

The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Diencephalon: Hypothalamus and Coordination01:23

Diencephalon: Hypothalamus and Coordination

The hypothalamus is a small yet highly complex and essential brain region that plays a crucial role in regulating various bodily functions. Anatomically, it is located at the base of the brain, just above the brainstem and below the thalamus, forming part of the limbic system.
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
Hierarchy of Motor Control01:18

Hierarchy of Motor Control

The hierarchy of motor control refers to the different levels of organization and processing involved in controlling movement in the body. These levels range from higher cortical areas involved in planning and decision-making to lower spinal cord reflexes that respond automatically to external stimuli.
Cerebral Hemispheres01:05

Cerebral Hemispheres

The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
Lateralization01:28

Lateralization

Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Group Joint ICA (gjICA): A Method for Multimodal Fusion of Concurrent EEG and fMRI Data.

Human brain mapping·2026
Same author

Aberrant recovery of timescale-aligned amplitude balance links to symptoms and cognition in schizophrenia.

Translational psychiatry·2026
Same author

Multimodal subspace independent vector analysis effectively captures latent relationships between brain structure and function.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

Structure-function coupling of large-scale cortical networks across the lifespan is spectrally specific.

Communications biology·2026
Same author

Modeling Complex Effects and Individual Variability in Multi-Paradigm fMRI with Nonlinear Mixed Models.

bioRxiv : the preprint server for biology·2026
Same author

Brain regions with gestational age differences mediate cognition in adolescents born very premature.

Communications biology·2026

Related Experiment Video

Updated: Jun 6, 2026

Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

Large-scale brain dynamics are organized by a directional coordination hierarchy.

Sir-Lord Wiafe1, Najme Soleimani1, Zening Fu1

  • 1Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, GA 30303, USA.

Biorxiv : the Preprint Server for Biology
|June 5, 2026
PubMed
Summary

Resting-state brain activity shows directional coordination reflecting cortical hierarchy. Schizophrenia alters this organization, impacting brain flexibility and offering clinical insights.

Keywords:
Complex-valued phase synchrony (CVPS)Cortical hierarchyDirectional coordination dynamicsResting-state fMRISchizophrenia

More Related Videos

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions
08:06

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Published on: February 15, 2021

Related Experiment Videos

Last Updated: Jun 6, 2026

Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions
08:06

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Published on: February 15, 2021

Area of Science:

  • Neuroscience
  • Systems Neuroscience
  • Cognitive Neuroscience

Background:

  • The cortical hierarchy organizes brain structure and function.
  • Its continuous expression in spontaneous neural activity is not well understood.

Purpose of the Study:

  • To investigate the organization of resting-state brain dynamics along a directional coordination axis.
  • To identify recurrent coordination modes and their stability.
  • To examine alterations in this organization in schizophrenia.

Main Methods:

  • Analysis of directional interregional coordination dynamics in resting-state fMRI data.
  • Identification of three coordination regimes: feedback-dominated, feedforward-dominated, and integrative.
  • Characterization of the coordination landscape across four independent cohorts.
  • Assessment of alterations in schizophrenia and correlation with clinical variables.

Main Results:

  • Resting-state brain dynamics exhibit a directional coordination axis mirroring hierarchical information flow.
  • Three recurrent coordination modes (feedback, feedforward, integrative) form a stable, low-dimensional landscape.
  • Schizophrenia reorganizes this landscape, reducing feedback persistence and increasing integrative persistence, leading to altered dynamics.
  • These alterations correlate with symptom severity, cognition, and medication.

Conclusions:

  • Directional functional dynamics are a fundamental property of large-scale brain organization.
  • Schizophrenia involves a selective reorganization of this dynamic landscape.
  • These findings provide a clinically informative axis for understanding brain function and dysfunction.