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Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
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Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

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Systemic inflammatory indexes mediate cardiac injury following intracerebral hemorrhage

Tao Ran1, Gui Li1, Tian-Tian Wang1

  • 1Department of Cardiovascular Medicine, Cardiovascular Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Frontiers in Cardiovascular Medicine
|June 5, 2026
PubMed

Insights

Inflammatory markers like MLR, SIRI, and AISI are linked to cardiac injury after intracerebral hemorrhage. These indicators mediate the brain-heart axis, impacting patient outcomes.

Area of Science:

  • Neuroscience
  • Cardiology
  • Inflammation Research

Background:

  • Intracerebral hemorrhage (ICH) frequently causes cardiac injury, worsening prognosis.
  • Systemic inflammation is a key mediator in the brain-heart axis following neurological events.
  • Understanding inflammation's role is crucial for managing ICH complications.

Purpose of the Study:

  • To investigate the association between composite inflammatory indices and acute cardiac injury post-ICH.
  • To explore the mediating role of inflammation in the brain-heart axis after ICH.

Main Methods:

  • Retrospective cohort study of 562 ICH patients (2017-2022).
  • Calculated composite inflammatory indices (MLR, SIRI, AISI, etc.) from blood counts.
  • Defined acute cardiac injury by hs-cTnT levels and ECG abnormalities.
  • Used multivariable logistic regression and mediation analyses.

Main Results:

  • Acute cardiac injury occurred in 29.5% of patients.
  • Elevated MLR, SIRI, and AISI independently predicted cardiac injury.
  • These indices partially mediated the association between lower GCS scores and cardiac injury.
  • A pathway of lower GCS → elevated SIRI → increased hs-cTnT → higher mortality was identified.

Conclusions:

  • Monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SIRI), and all-grade inflammation score (AISI) are independent predictors of cardiac injury after ICH.
  • These inflammatory markers significantly mediate the brain-heart axis following intracerebral hemorrhage.
Abstract

Keywords:
brain-heart axiscardiac injuryinflammatory indicesintracerebral hemorrhagesystemic inflammation

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