Cross-Modal Characterization of Infant Cry: Validation of a Chest-Surface Accelerometer in Extracting Acoustic Vocal...

Infant cry acoustics provide a promising window into early neurodevelopment and may serve as scalable biomarkers for neurodevelopmental disorders. However, conventional microphone-based recordings are highly susceptible to environmental noise and raise privacy concerns in real-world clinical settings. Chest-surface accelerometers may offer a robust alternative by capturing vibrations directly from the larynx. We evaluated the validity of a chest-mounted accelerometer (ACC) for infant cry analysis by comparing acoustic features derived from ACC and simultaneously recorded microphone (MIC) signals during routine vaccination visits. The final sample included 85 infants (41 at 4 months; 44 at 12 months) from a diverse pediatric population. Seven vocal measures were extracted from both modalities, including fundamental frequency (F0), jitter, shimmer, cepstral peak prominence (CPP), and harmonics-to-noise ratio (HNR). Agreement and consistency between modalities were assessed using intraclass correlation coefficients (ICCs). F0 demonstrated excellent agreement between ACC and MIC recordings (ICC > 0.94). Jitter measures also showed good-to-excellent agreement, while CPP demonstrated moderate agreement. Shimmer and HNR showed lower absolute agreement and systematic bias between modalities, reflecting possible differences in signal transmission and noise sensitivity. In summary, chest-surface accelerometers can reliably capture several clinically relevant acoustic features of infant cry, particularly temporal measures of F0 and jitter. This approach offers a noise-robust and privacy-preserving alternative to microphone-based recordings, supporting its potential use in scalable clinical and developmental research applications.