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Related Experiment Video

Updated: Jun 6, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Correlation between double-stranded DNA and rheumatoid arthritis.

Mingwei Lv^1,2, Yirui Wang³, Juan Du⁴

¹School of Basic Medicine, North China University of Science and Technology, Tangshan, Hebei, 063210, China.

Central-European Journal of Immunology

|June 5, 2026

Summary

Circulating double-stranded DNA (dsDNA) levels are elevated in rheumatoid arthritis (RA) patients and influenced by seasonal weather. This dsDNA increase impacts immune responses, potentially affecting RA progression.

Keywords:

AIM2 double-stranded DNA rheumatoid arthritis season temperature

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Published on: May 16, 2025

Area of Science:

Immunology
Environmental Medicine
Rheumatology

Background:

Rheumatoid arthritis (RA) is a chronic autoimmune disease with environmental influences.
Double-stranded DNA (dsDNA) acts as an antigen in autoimmune diseases and is linked to meteorological factors.
The interplay between dsDNA levels, RA inflammation, and seasonal weather is not well understood.

Purpose of the Study:

To investigate the relationship between serum dsDNA levels, RA inflammatory mechanisms, and seasonal meteorological factors.
To determine if dsDNA levels in RA patients differ from healthy controls and correlate with climate data.

Main Methods:

Serum dsDNA levels were quantified in RA patients and healthy controls.
Correlations between dsDNA levels and historical seasonal meteorological data were analyzed.
Gene expression of dsDNA receptors and related inflammatory factors was assessed using quantitative PCR.

Main Results:

RA patients exhibited significantly higher serum dsDNA levels compared to controls.
Upregulation of genes associated with dsDNA receptors, inflammasomes, type I interferons (IFN α1, IFN β1), and low-density lipoprotein was observed in RA patients.
dsDNA levels were found to be influenced by seasonal climatic factors.

Conclusions:

Elevated dsDNA levels in RA patients are associated with seasonal climate variations.
Increased dsDNA enhances the expression of inflammasome-related factors and type I IFN, contributing to RA inflammation.
These findings suggest a link between climate variability and RA progression, warranting further mechanistic studies.