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Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
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Published on: October 23, 2015

Bioactive, PDMS-containing shape memory composite scaffolds with accelerated degradation rates.

Brandon M Nitschke1, MaryGrace N Wahby1, Kaylee M Breining2

  • 1Department of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, United States.

Polymer
|June 5, 2026
PubMed
Summary
This summary is machine-generated.

This study developed advanced shape memory polymer scaffolds for craniomaxillofacial bone repair. The new scaffolds incorporate polydimethylsiloxane and Bioglass, enhancing bone regeneration and degradation properties.

Keywords:
BioactivityBioglassCompositePolydimethylsiloxanePolysiloxaneRegenerative engineeringScaffoldSemi-interpenetrating network

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Polymer Chemistry

Background:

  • Craniomaxillofacial (CMF) bone defects require effective regenerative engineering solutions.
  • Previous work established poly(ε-caprolactone) (PCL)-based shape memory polymer (SMP) scaffolds for conformal fitting.
  • Incorporating polydimethylsiloxane-dimethacrylate (PDMS-DMA) and 45S5 Bioglass® (BG) can enhance mineralization and degradation.

Purpose of the Study:

  • To prepare and characterize polydimethylsiloxane (PDMS)-containing composite SMP scaffolds with varying compositions and Bioglass® (BG) concentrations.
  • To evaluate the effects of PDMS and BG on scaffold properties, including shape memory behavior, brittleness, degradation, and bioactivity.

Main Methods:

  • Fabrication of PCL/PDMS co-matrix scaffolds and PCL/PLLA/PDMS co-matrix semi-interpenetrating networks (semi-IPNs).
  • Inclusion of BG (5 and 10 wt%) concentrated on pore walls using a modified solvent-cast particulate leaching (SCPL) method.
  • Assessment of shape memory properties, in vitro degradation, and hydroxyapatite (HAp) mineralization in simulated body fluid (SBF).

Main Results:

  • PDMS-containing scaffolds maintained shape memory characteristics and exhibited reduced brittleness.
  • In vitro degradation rates were accelerated in PDMS-containing composites due to polymer phase separation and BG hydrophilicity.
  • Significant bioactivity was observed, with HAp mineralization initiating within 1 day in simulated body fluid (SBF).

Conclusions:

  • Composite SMP scaffolds incorporating PDMS and BG demonstrate promising properties for CMF bone defect regeneration.
  • The developed scaffolds offer tunable degradation, enhanced bioactivity, and preserved shape memory functionality.
  • These findings support the potential of these advanced biomaterials for self-fitting, regenerative CMF defect treatment.