Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Quantitative Electrostatic Potential Descriptor Enables Deep Learning-Accelerated Discovery of High-Performance Lithium-Ion Battery Electrolytes.

Angewandte Chemie (International ed. in English)·2026
Same author

Endogenous peptide derived from c-Cbl-associated protein counteracts its inhibitory effect on enteric neural crest cell colonization in Hirschsprung disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Towards a unified principal indicator system for global water quality assessment.

Water research·2026
Same author

Crab Shell Inspired Chitin/β-Tricalcium Phosphate Screws as Orthopedic Implants.

Biomacromolecules·2026
Same author

Mako robot-assisted unicompartmental knee arthroplasty mitigates the impact of surgeon handedness.

Journal of robotic surgery·2026
Same author

Baseline Tumor Proliferation and Ki-67 Are Associated With Pathological Response to Neoadjuvant Chemoimmunotherapy in Non-Small Cell Lung Cancer.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2026

Related Experiment Video

Updated: Jun 6, 2026

Rotating the Intraocular Lens to Prevent Posterior Capsular Opacification in Cataract Surgeries
04:59

Rotating the Intraocular Lens to Prevent Posterior Capsular Opacification in Cataract Surgeries

Published on: July 7, 2023

Musculoskeletal disorders: does cuproptosis hold the key?

Chenglong Wang1, Dengshang Liu1, Yu Ye1

  • 1Spinal Surgery Department, Mianyang Orthopaedic Hospital, Mianyang, Sichuan, China.

Frontiers in Cell and Developmental Biology
|June 5, 2026
PubMed
Summary

Cuproptosis, a cell death pathway involving copper, is explored for its role in musculoskeletal disorders. Research is needed to understand its mechanisms and therapeutic potential in conditions like osteoarthritis and osteoporosis.

Keywords:
cuproptosiscuproptosis-related genesintervertebral disc degenerationmusculoskeletal disordersosteoarthritisosteoporosisrheumatoid arthritis

More Related Videos

Measuring 3D In-vivo Shoulder Kinematics using Biplanar Videoradiography
06:09

Measuring 3D In-vivo Shoulder Kinematics using Biplanar Videoradiography

Published on: March 12, 2021

Related Experiment Videos

Last Updated: Jun 6, 2026

Rotating the Intraocular Lens to Prevent Posterior Capsular Opacification in Cataract Surgeries
04:59

Rotating the Intraocular Lens to Prevent Posterior Capsular Opacification in Cataract Surgeries

Published on: July 7, 2023

Measuring 3D In-vivo Shoulder Kinematics using Biplanar Videoradiography
06:09

Measuring 3D In-vivo Shoulder Kinematics using Biplanar Videoradiography

Published on: March 12, 2021

Area of Science:

  • Biochemistry
  • Cell Biology
  • Orthopedics

Background:

  • Cuproptosis is a novel programmed cell death pathway.
  • It is triggered by copper accumulation and affects mitochondria and protein stability.
  • Its role in musculoskeletal disorders is largely unknown.

Purpose of the Study:

  • To review the molecular mechanisms of cuproptosis in musculoskeletal diseases.
  • To evaluate cuproptosis as a potential disease-modifying factor.
  • To identify translational challenges and future research directions.

Main Methods:

  • Comprehensive literature review.
  • Synthesis of current knowledge on cuproptosis.
  • Analysis of its role in various musculoskeletal conditions.

Main Results:

  • Cuproptosis involves copper toxicity impacting cellular metabolism and proteostasis.
  • Emerging evidence suggests its relevance in conditions like osteoarthritis and osteoporosis.
  • Significant knowledge gaps exist regarding its specific mechanisms and therapeutic applications.

Conclusions:

  • Cuproptosis presents a potential new avenue for understanding and treating musculoskeletal disorders.
  • Further research is crucial to elucidate its mechanisms and clinical utility.
  • Addressing translational challenges is key for future therapeutic development.