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Musculoskeletal disorders: does cuproptosis hold the key?
Chenglong Wang1, Dengshang Liu1, Yu Ye1
1Spinal Surgery Department, Mianyang Orthopaedic Hospital, Mianyang, Sichuan, China.
Frontiers in Cell and Developmental Biology
|June 5, 2026
Summary
Cuproptosis, a cell death pathway involving copper, is explored for its role in musculoskeletal disorders. Research is needed to understand its mechanisms and therapeutic potential in conditions like osteoarthritis and osteoporosis.
Area of Science:
- Biochemistry
- Cell Biology
- Orthopedics
Background:
- Cuproptosis is a novel programmed cell death pathway.
- It is triggered by copper accumulation and affects mitochondria and protein stability.
- Its role in musculoskeletal disorders is largely unknown.
Purpose of the Study:
- To review the molecular mechanisms of cuproptosis in musculoskeletal diseases.
- To evaluate cuproptosis as a potential disease-modifying factor.
- To identify translational challenges and future research directions.
Main Methods:
- Comprehensive literature review.
- Synthesis of current knowledge on cuproptosis.
- Analysis of its role in various musculoskeletal conditions.
Main Results:
- Cuproptosis involves copper toxicity impacting cellular metabolism and proteostasis.
- Emerging evidence suggests its relevance in conditions like osteoarthritis and osteoporosis.
- Significant knowledge gaps exist regarding its specific mechanisms and therapeutic applications.
Conclusions:
- Cuproptosis presents a potential new avenue for understanding and treating musculoskeletal disorders.
- Further research is crucial to elucidate its mechanisms and clinical utility.
- Addressing translational challenges is key for future therapeutic development.
