Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dose Response Curve: Conventional Versus Nonmonotonic01:21

Dose Response Curve: Conventional Versus Nonmonotonic

The correlation between a drug's dosage and its impact on a biological system is a cornerstone of pharmacology and toxicology. Conventional dose–response curves, which include graded and quantal relationships, are key to this understanding. Graded dose–response curves depict the spectrum of a biological reaction to different doses within an individual, indicating that as the drug dosage increases, so does the intensity of the response. On the other hand, quantal dose–response relationships...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-class segmentation of aortic branches and zones in computed tomography angiography: The AortaSeg24 challenge.

Medical image analysis·2026
Same author

Respiratory motion augmentation for personalized super-resolution (RMApSR) of 3D cine MR images in MRI-guided radiotherapy.

Medical image analysis·2026
Same author

A proof-of-concept automated method for accurate skin dosimetry: correcting overestimated surface dose measurements.

Physics in medicine and biology·2026
Same author

A feasibility study on a machine-learning-based quality assurance tool for spot-scanning proton therapy using delivery log files and treatment plans.

Physics and imaging in radiation oncology·2026
Same author

Prevalence of polypharmacy and its association with clinical outcomes in kidney transplant recipients : results from the KNOW-KT study.

Kidney research and clinical practice·2026
Same author

Susceptibility of Large Language Models to User-Driven Factors in Medical Queries.

Journal of healthcare informatics research·2026

Related Experiment Video

Updated: Jun 6, 2026

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

Published on: September 4, 2017

Automated dose-gradient curve and dose-volume histogram analysis platform: development, validation, and clinical

Han-Back Shin1, Wonyoung Cho2, Young Eun Choi1

  • 1Department of Radiation Oncology, Gachon University Gil Medical Center, Incheon, Republic of Korea.

Frontiers in Oncology
|June 5, 2026
PubMed
Summary

This study introduces an automated platform for analyzing dose gradient curves (DGCs) in radiotherapy, significantly reducing analysis time and enabling faster, more accurate plan assessments. The platform enhances radiotherapy plan evaluation by providing rapid DGC analysis and integrated quality grading.

Keywords:
dose fall-offdose gradient curvedose-volume histogramplan quality evaluationstereotactic radiotherapy

More Related Videos

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Related Experiment Videos

Last Updated: Jun 6, 2026

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

Published on: September 4, 2017

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Area of Science:

  • Radiotherapy physics
  • Medical imaging analysis
  • Computational oncology

Background:

  • Conformal radiotherapy requires steep dose fall-off to protect organs at risk (OARs).
  • Dose-volume histograms (DVHs) lack spatial information for dose fall-off assessment.
  • Dose gradient curves (DGCs) offer quantitative assessment but are limited by time-consuming manual processing.

Purpose of the Study:

  • To develop and validate an automated platform for DGC and DVH analysis.
  • To enable accurate and rapid dose gradient evaluation for radiotherapy plan assessment.

Main Methods:

  • Automated processing of DICOM RT dose, structure, and optional RT Plan files.
  • Computation of differential and cumulative dose gradient indices (dDGI, cDGI) and DVH metrics.
  • Validation using AAPM TG-119 phantom datasets and 142 Gamma Knife stereotactic radiosurgery plans for vestibular schwannoma.

Main Results:

  • Platform reduced computation time from over 2 hours to under 10 seconds (>99.8% efficiency improvement).
  • TG-119 cases met PTV coverage and OAR tolerance recommendations.
  • Clinical validation showed strong correlation between dDGI and target volume (r=0.885), independent of conformity index (r=0.040).
  • Reproducibility analysis demonstrated excellent agreement (dDGI r=0.987).

Conclusions:

  • The platform provides rapid, automated DGC analysis for routine radiotherapy plan evaluation.
  • Integrated quality grading bridges quantitative metrics with clinical decisions.
  • The tool complements conventional DVH-based assessment for improved plan quality.