Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

Adaptive Mechanisms in Cancer Cells

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

Adaptive Mechanisms in Cancer Cells

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

Cancer

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Paipu framework enables creation of a large-scale mammalian cancer transcriptomics atlas.

bioRxiv : the preprint server for biology·2026

Same author

Equitable machine learning counteracts ancestral bias in precision medicine.

Nature communications·2025

Same author

Bringing the Genomic Revolution to Comparative Oncology: Human and Dog Cancers.

Annual review of biomedical data science·2024

Same author

Equitable machine learning counteracts ancestral bias in precision medicine, improving outcomes for all.

Research square·2023

Same author

Positive selection in noncoding genomic regions of vocal learning birds is associated with genes implicated in vocal learning and speech functions in humans.

Genome research·2021

Same author

Universal nomenclature for oxytocin-vasotocin ligand and receptor families.

Nature·2021

Search research articles

Related Experiment Video

Updated: Jun 6, 2026

Unveiling Therapeutic Opportunities with Melanoma Patient-derived Organoid Models

Unveiling Therapeutic Opportunities with Melanoma Patient-derived Organoid Models

Published on: September 6, 2024

Leveraging Dog Models to Uncover Human Cancer Insights.

Geesa Daluwatumulle¹, Leslie A Smith¹, Nathan Glen¹

¹Department of Computer & Information Science & Engineering, University of Florida, 1889 Museum Road, Gainesville, 32611, FL, USA.

Research Square

|June 5, 2026

Summary

Dogs serve as an excellent comparative model for many human cancers, particularly adult tumors. This study quantifies canine cancer transcriptomic similarities to human cancers, aiding comparative oncology research.

Keywords:

RNA-seq adult cancer comparative transcriptomics dog model pediatric

More Related Videos

Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model

Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model

Published on: August 16, 2020

Related Experiment Videos

Last Updated: Jun 6, 2026

Unveiling Therapeutic Opportunities with Melanoma Patient-derived Organoid Models

Unveiling Therapeutic Opportunities with Melanoma Patient-derived Organoid Models

Published on: September 6, 2024

Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model

Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model

Published on: August 16, 2020

Area of Science:

Comparative genomics
Translational oncology
Bioinformatics

Background:

Comparative genomics offers unique insights into human diseases by analyzing related species.
Dogs share environmental factors, genetics, and develop similar tumors to humans, making them valuable models.
Existing research lacks a comprehensive pancancer comparative transcriptomic analysis between human and dog cancers.

Purpose of the Study:

To conduct a pancancer comparative transcriptomic analysis of human and dog cancers.
To systematically quantify the effectiveness of canine tumors as models for human adult and pediatric cancers.
To develop a scalable method for identifying effective animal models in comparative oncology.

Main Methods:

Pancancer analysis of 5,875 samples (913 dogs, 4,962 humans) across 11 tumor types.
Development of a quantitative formula to assess transcriptomic similarities between human and dog cancers.
Comparative analysis of adult and pediatric human cancer samples against canine counterparts.

Main Results:

Dogs demonstrate significant transcriptomic similarities to many human cancers, validating their use as a model system.
Canine models are generally more effective for adult human cancers than pediatric cancers, with exceptions like gliomas and sarcomas.
The study provides a quantitative framework for evaluating and selecting appropriate animal models for specific human cancer types.

Conclusions:

Dogs represent a highly effective preclinical model for a broad spectrum of human cancers.
The developed methodology facilitates the rapid and accurate identification of suitable model systems for human cancer research.
This work advances comparative oncology by enabling new cross-species studies of cancer biology and treatment.