Related Experiment Video

Updated: Jun 6, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Evaluation of Blood Pressure Variability With Clevidipine Infusion in Patients With Acute Cerebrovascular Disease

Caitlin S Brown1, Tuba Chaudhry2, Kristin Cole3

  • 1Pharmacy, Mayo Clinic, Rochester, USA.

Cureus
|June 5, 2026
PubMed

Insights

Clevidipine infusions in acute cerebrovascular disease showed moderate blood pressure variability (BPV). While reaching targets, the drug was associated with neurological decline and acute kidney injury in some patients.

Area of Science:

  • Neurology
  • Cardiology
  • Pharmacology

Background:

  • Blood pressure variability (BPV) is linked to poor outcomes in acute cerebrovascular diseases.
  • Acute hypertension management often involves intravenous antihypertensives.

Purpose of the Study:

  • To assess clevidipine's safety and efficacy in achieving blood pressure targets.
  • To evaluate clevidipine's impact on blood pressure variability in acute cerebrovascular conditions.

Main Methods:

  • Prospective, single-arm, observational study.
  • Adult patients with acute ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, or PRES requiring clevidipine.
  • Primary outcomes: systolic BPV in the first hour, acute neurological decline, and acute kidney injury.

Main Results:

  • Thirty patients enrolled; median age 64, 63% with intracerebral hemorrhage.
  • Median time to blood pressure goal was 20 minutes.
  • Mean systolic BPV (SD) was 17.2 in the first hour and 16.4 at 24 hours. AKI occurred in 20%, and neurological decline in 37%.

Conclusions:

  • This study provides initial observations on clevidipine use and BPV in cerebrovascular disease.
  • Limitations include a small sample size and observational design.
  • Further comparative studies are needed to evaluate antihypertensive strategies and BPV.
Abstract

Keywords:
blood pressurecerebrovascular diseaseclevidipineintracranial hemorrhagesneurology and critical care

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Assessing Blood pressure using a doppler ultrasound01:19

Assessing Blood pressure using a doppler ultrasound

To obtain accurate blood pressure measurements in clinical settings, especially when traditional methods are insufficient, healthcare professionals utilize the Doppler ultrasound technique. This method uses high-frequency sound waves to detect blood flow within the arteries, which is crucial for patients with conditions that complicate circulatory system assessment.
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:
Assessment of blood pressure in brachial artery(two-step method)01:23

Assessment of blood pressure in brachial artery(two-step method)

Measuring blood pressure is a fundamental skill in healthcare that aids in diagnosing and monitoring hypertension and other cardiovascular conditions. An aneroid sphygmomanometer, commonly used in clinical settings, offers a manual and precise method for blood pressure measurement. The technique for using this instrument involves specific steps that must be carefully executed to ensure accuracy. The following detailed description outlines a two-step technique for assessing blood pressure using...
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
Assessment of blood pressure in brachial artery(one-step method)01:15

Assessment of blood pressure in brachial artery(one-step method)

This procedural guide systematically measures blood pressure using an oscillometric digital sphygmomanometer, emphasizing accuracy, patient safety, and comfort.
Prepare for the Procedure:
Alterations in Blood Pressure01:30

Alterations in Blood Pressure

Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart beats)...