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Related Experiment Video

Updated: Jun 6, 2026

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Published on: July 10, 2014

Somatosensory cortex neuronal integrity is altered after stroke.

Rafay Cheema¹, Nawal Cheema², Andrew Apostol²

¹Boston University, Boston, MA, United States.

Frontiers in Human Neuroscience

|June 5, 2026

Summary

Stroke survivors show reduced neuronal integrity in the ipsilesional primary somatosensory cortex (S1), impacting hand function recovery. This neuronal dysfunction in S1 correlates with hand impairment in chronic stroke patients, highlighting potential therapeutic targets.

Keywords:

N-acetylaspartate glutamate-glutamine complex hand impairment somatosensory cortex subcortical stroke

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Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with ¹⁸F-FDG

Published on: December 28, 2014

Area of Science:

Neuroscience
Metabolic Imaging
Stroke Rehabilitation

Background:

Sensorimotor remapping is key for post-stroke hand function recovery.
While motor remapping is studied, somatosensory cortical remapping remains under-investigated.
This study examines metabolic changes in the ipsilesional primary somatosensory cortex (S1) after stroke.

Purpose of the Study:

To investigate the metabolic status of the ipsilesional S1 in stroke patients.
To explore the relationship between S1 metabolic changes and hand impairment.
To extend previous findings on metabolic alterations in stroke-affected brain regions.

Main Methods:

MR Spectroscopy measured N-acetylaspartate and glutamate-glutamine in the S1 hand territory of 14 stroke patients and 10 controls.
Patients had moderate hand impairment but no sensory deficits.
Subgroup analysis included subacute (≤6 months) and chronic (>6 months) stroke phases.

Main Results:

Stroke patients exhibited significantly lower N-acetylaspartate (neuronal integrity marker) compared to controls, especially in the subacute phase.
No significant alterations in glutamate-glutamine levels were observed.
N-acetylaspartate correlated with glutamate-glutamine in patients, and with hand impairment in chronic stroke survivors.

Conclusions:

Preliminary findings suggest neuronal mitochondrial dysfunction in ipsilesional S1, correlating with reduced cortical excitability.
S1 neuronal dysfunction is linked to hand impairment in chronic stroke.
Further longitudinal studies with larger cohorts are recommended.