Related Experiment Video
Updated: Jun 6, 2026
05:28
A Semi-Quantitative Drug Affinity Responsive Target Stability (DARTS) assay for studying Rapamycin/mTOR interaction
Published on: August 27, 2019
[Using activity-based protein profiling method to explore the antitumor targets of spiramycin derivatives].
Ren-Yu Yang1,2, Ting-Ze Feng1,2, Shao-Jun Pei1,2
1Dalian Institute of Chemical Physics，Chinese Academy of Sciences，Dalian 116023，China.
Se Pu = Chinese Journal of Chromatography
|June 5, 2026
Summary
This study reveals that amyloid precursor protein (APP) is crucial for the antitumor effects of spiramycin derivatives like n-hexanoyl spiramycin (h-SPM). Activity-based protein profiling identified APP as a key target, validating the potential of these compounds in cancer therapy.
Area of Science:
- Chemoproteomics and Drug Discovery
- Cancer Biology and Therapeutics
- Macrolide Antibiotic Derivatives
