Related Experiment Video

Updated: Jun 6, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

[Expression of Concern] Antitumor activity of Notch‑1 inhibition in human colorectal carcinoma cells

Wangdi Liao1, Guohua Li1, Yu You1

  • 1Department of Gastroenterology, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

Oncology Reports
|June 5, 2026
PubMed

Insights

An investigation is underway regarding potential data reuse in cell morphology experiments. The Editor is examining figure panels for scientific integrity concerns, awaiting author responses.

Area of Science:

  • Oncology
  • Cell Biology
  • Scientific Publishing Ethics

Background:

  • Concerns raised by a reader regarding specific figures in a published paper.
  • Potential reuse of data panels ('NC' vs. 'Control') in cell morphology experiments.

Purpose of the Study:

  • To address potential issues with scientific integrity.
  • To notify readers of an ongoing investigation into data presentation.

Main Methods:

  • Review of figures (Fig. 4C, 9B) for data consistency.
  • Contacting authors for explanation of apparent data reuse.
  • Editorial investigation into scientific integrity.

Main Results:

  • Apparent matching of 'NC' data panel in Fig. 4C with 'Control' data panel in Fig. 9B.
  • Images presented at different sizes despite apparent data similarity.

Conclusions:

  • An Expression of Concern has been issued due to potential scientific integrity issues.
  • The investigation is ongoing pending author response.
Keywords:
DAPTNotch signaling pathwayapoptosiscolorectal carcinoma

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