Long non-coding RNA maternally expressed gene 3 (MEG3) rs4081134 gene polymorphism and preeclampsia risk

Preeclampsia (PE), a significant challenge for health systems, is a hypertensive disorder of pregnancy. Some studies have suggested that long non-coding ribonucleic acids play a major role in the pathogenesis of PE by regulating the biological behaviors of maternal vascular smooth muscle cells and trophoblasts. In this study, the impact of the maternally expressed gene 3 (MEG3) rs4081134 gene polymorphism on susceptibility to PE has been evaluated.

We conducted a case-control study comprising 130 PE patients and 140 normotensive pregnant women with normal gestational outcomes. Genotype analysis was performed using the polymerase chain reaction-restriction fragment length polymorphism method.

A significant association was evident between the AA genotype and PE risk under the recessive model, indicating that these may serve as protective factors against the development of PE. No significant relationships were detected between other genotypes, genetic models, or allelic distributions and PE risk. Additionally, among pregnant women with PE, a notable correlation was observed between newborn birth weight and the rs4081134 polymorphism in the MEG3 gene.

We found a significant association between the AA genotype, as well as the recessive model of the MEG3 rs4081134 gene polymorphism, and PE deployment. Among women diagnosed with PE, MEG3 rs4081134 gene polymorphism was significantly associated with newborn's birth weight.