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Related Experiment Video

Updated: Jun 6, 2026

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

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Published on: February 6, 2019

Baclofen Modulates Neural Intrinsic Functional Connectivity in Treatment-Seeking Individuals With Alcohol Use

Warren B Logge1,2, Tristan P Hurzeler1,2, Paul S Haber1,3

  • 1Edith Collins Centre for Translational Research in Alcohol, Drugs and Toxicology, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, New South Wales, Australia.

Alcohol, Clinical & Experimental Research
|June 5, 2026
PubMed
Summary

High-dose baclofen significantly altered brain connectivity in individuals with alcohol use disorder (AUD), affecting reward and attention networks. These neurobiological changes suggest baclofen

Keywords:
alcohol use disorderbaclofenfunctional connectivityfunctional magnetic resonance imagingrandomized controlled trial

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Published on: June 23, 2023

Area of Science:

  • Neuroscience
  • Pharmacology
  • Clinical Trials

Background:

  • Chronic alcohol use disrupts brain networks crucial for reward and stress regulation, underlying alcohol use disorder (AUD).
  • Baclofen, a GABAB receptor agonist, shows promise in reducing alcohol consumption and cue-elicited neural responses.
  • The impact of baclofen on intrinsic functional brain connectivity in AUD remains under investigation.

Purpose of the Study:

  • To investigate the dose-specific effects of baclofen on intrinsic resting-state functional connectivity in individuals with AUD.
  • To explore associations between functional connectivity changes and clinical outcomes like drinking days and abstinence.

Main Methods:

  • A 12-week, double-blind, placebo-controlled randomized clinical trial involving 29 participants with AUD.
  • Participants received placebo, low-dose baclofen (30 mg/day), or high-dose baclofen (75 mg/day).
  • Resting-state fMRI data were analyzed using a data-driven parcellation approach to assess brain connectivity.

Main Results:

  • High-dose baclofen, compared to placebo, induced significant alterations in intrinsic connectivity within reward, stress, attention, and salience networks.
  • Increased connectivity was noted between the somatomotor network and hypothalamus/reward regions; decreased connectivity was observed within salience and attentional networks.
  • Low-dose baclofen did not yield significant connectivity changes; exploratory analyses showed trends linking connectivity to abstinence.

Conclusions:

  • High-dose baclofen modulates intrinsic brain connectivity in networks critical for attention and stress regulation in AUD.
  • While not statistically significant, observed connectivity differences suggest potential relevance to treatment response in AUD.
  • Findings support baclofen's potential as a dose-dependent pharmacotherapy for AUD, warranting larger studies to confirm clinical outcome relationships.