Related Experiment Video
Updated: Jun 6, 2026
05:53
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Relationship Between Central Sensitization and Genetic Polymorphisms-A Case-Control Study in Fibromyalgia.
Nicolas Macian1, Christian Dualé1,2, Marine Delay1
1Plateforme D'investigation Clinique (Inserm CIC1405), CHU Clermont-Ferrand, Clermont-Ferrand, France.
European Journal of Pain (London, England)
|June 5, 2026
Summary
This study investigated genetic factors in fibromyalgia, finding no direct link between 60 candidate genes and central sensitization (CS). Further research is needed to understand the genetic basis of fibromyalgia and CS.
Area of Science:
- Neuroscience
- Genetics
- Pain Research
Background:
- Fibromyalgia is a chronic pain syndrome linked to central sensitization (CS).
- Genetic factors may influence CS and fibromyalgia pathogenesis.
- This study explored the genetic underpinnings of CS in fibromyalgia patients.
Purpose of the Study:
- To investigate the genetic determinants of central sensitization (CS) in fibromyalgia.
- To explore the association between candidate genes and fibromyalgia.
- To identify potential genetic pathways involved in fibromyalgia pathogenesis.
Main Methods:
- 201 women with fibromyalgia and 40 healthy controls were included.
- Nociceptive flexion reflex (NFR) threshold served as a surrogate marker for CS.
- Genotyping of 60 candidate genes was performed on all participants.
Main Results:
- NFR threshold was significantly lower in fibromyalgia patients compared to controls (p=0.0003).
- Initial analysis revealed associations between fibromyalgia and polymorphisms in TNF, TACR1, and IL10 genes.
- After adjusting for NFR threshold, TACR1, FAAH, HTR1A, and MYT1L showed associations, but these were non-significant after Bonferroni correction.
Conclusions:
- Central sensitization (CS) is a key feature of fibromyalgia.
- No significant association was found between the NFR threshold and the 60 selected candidate gene polymorphisms.
- Findings guide future research in larger, well-phenotyped cohorts to explore fibromyalgia's genetic pathways.
Related Concept Videos
01:29Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
01:11Genome-wide Association Studies-GWAS
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
01:11Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
01:28Human Genetics
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
01:27Principles of Pharmacogenetics: Types of Genetic Variants
The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
01:05Single Nucleotide Polymorphisms-SNPs
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...