Related Experiment Video
Updated: Jun 6, 2026
Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure
Published on: July 30, 2009
Molecular-Structural MRI Mismatch for Preoperative Risk Stratification of Pediatric Neuroblastoma
Junjie Wen1, Wenqi Wang2, Xuan Jia2
1Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Room 418, Teaching Building 6, Yuquan Campus, 38 Zheda Road, Hangzhou 310027, Zhejiang, China.
Abstract:
Purpose To establish molecular-structural mismatch indexes and explore their potential for the preoperative risk stratification of individuals with pediatric neuroblastoma. Materials and Methods In this prospective study, 102 pediatric individuals with suspected neuroblastoma were initially enrolled and underwent structural MRI and amide proton transfer (APT) MRI from April 2019 to November 2023. A four-pool Lorentzian fitting model was employed to minimize motion artifacts and extract the APT signal from confounding factors, generating APT maps and APT-weighted (APTw) images. Novel molecular-structural mismatch images were then synthesized using APT maps, APTw images, and conventional structural MRI. The mean tumor region of interest values on APT, APTw, and mismatch images were compared across risk groups using Wilcoxon rank sum tests; receiver operating characteristic analysis was used to assess the performance of these values in risk stratification, and the DeLong test was used to evaluate differences in the area under the curve (AUC). Results The final analysis included 71 participants (mean ± SD age at examination, 45.8 months ± 31.6; 52 male individuals), comprising 42 participants at high risk and 29 at non-high risk. The mean tumor region of interest values on APT, APTw, and mismatch images were greater in those at high risk than those not at high risk (P < .05). The mean APTw value had an AUC of 0.68 (95% CI: 0.54, 0.80), and the APT map achieved an AUC of 0.76 (95% CI: 0.64, 0.87). The molecular-structural mismatch images had numerically higher AUC values, at 0.84 (95% CI: 0.75, 0.94) for APTw-T2w mismatch and 0.83 (95% CI: 0.74, 0.93) for APT-T2w mismatch, respectively, but there was no evidence of a difference (P > .05). Conclusion Molecular-structural mismatch demonstrates potential as a noninvasive approach for differentiating neuroblastoma risk groups among children. Keywords: Pediatrics, MRI, Statistics, Molecular Imaging-Cancer, Abdomen/GI Supplemental material is available for this article. © RSNA, 2026.
