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Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...

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Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
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Published on: December 10, 2016

Statement of Removal

Yousra Mikrat1,2, Anthony Adjamian1,2, Zineb Elidrissi1,2

  • 1Microbes Evolution Phylogeny and Infections (MEPHI), Aix-Marseille Université, France.

Emerging Microbes & Infections
|June 5, 2026
PubMed
Summary
This summary is machine-generated.

Genomic analysis of Clostridium butyricum strains revealed distinct plasmid profiles. These differences were associated with necrotizing enterocolitis (NEC) in preterm infants, suggesting a role in disease development.

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Area of Science:

  • Microbiology
  • Genomics
  • Neonatal Research

Background:

  • Necrotizing enterocolitis (NEC) is a severe, often fatal gastrointestinal disease affecting preterm infants.
  • Clostridium butyricum is found in the gut microbiome, but its role in NEC is not fully understood.

Purpose of the Study:

  • To investigate the genomic differences in Clostridium butyricum strains isolated from NEC patients and asymptomatic carriers.
  • To identify potential virulence factors associated with NEC development.

Main Methods:

  • Comparative genomic analysis of 32 Clostridium butyricum strains (25 asymptomatic, 7 NEC).
  • Phylogenetic analysis to determine strain clustering.
  • Plasmid profiling to identify genetic elements and their distribution.

Main Results:

  • Phylogenetic analysis identified two main clusters; Cluster 2 was predominantly associated with NEC patients.
  • Six plasmids were identified, varying in size and gene content.
  • Specific plasmid profiles were observed between clusters, including the largest Clostridium butyricum plasmid reported.
  • Plasmid differences correlated with NEC status.

Conclusions:

  • Genomic and plasmid profile variations in Clostridium butyricum are linked to NEC.
  • Specific plasmids may contribute to the virulence potential of Clostridium butyricum in NEC pathogenesis.
  • Further research into these plasmids could reveal therapeutic targets for NEC.