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Analysis of risk factors for postoperative wound healing in children with bone cysts

Muhan Yu1,2, Yuxi Su1,2

  • 1Department of Clinical Laboratory, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing, China.

Annals of Medicine
|June 5, 2026
PubMed

Insights

Inadequate antibiotic prophylaxis, lesion physeal involvement, and long operative times increase poor wound healing risk in pediatric bone cyst surgery. Optimizing antibiotics and identifying high-risk patients can prevent complications.

Area of Science:

  • Pediatric Orthopedics
  • Surgical Site Infections
  • Bone Tumors

Background:

  • Bone cysts are common benign lesions in children.
  • Postoperative wound healing complications are a significant concern.
  • Research on risk factors for poor wound healing in pediatric bone cyst surgery is limited.

Purpose of the Study:

  • To identify independent risk factors for poor postoperative wound healing in children undergoing surgery for bone cysts.
  • To analyze the association of demographic, lesion, and surgery-related variables with wound healing outcomes.

Main Methods:

  • Retrospective cohort analysis of 99 children with bone cysts treated surgically.
  • Data analyzed using univariate and multivariate logistic regression.
  • Variables assessed included antibiotic prophylaxis, physeal involvement, and operative time.

Main Results:

  • 13.1% of children experienced poor wound healing.
  • Independent risk factors identified: inadequate antibiotic prophylaxis (OR=9.808-34.161), physeal involvement (OR=7.764), and operative time ≥90 min (OR=8.597).

Conclusions:

  • Inadequate antibiotic prophylaxis, physeal involvement, and prolonged operative time are key risk factors for poor wound healing in pediatric bone cyst surgery.
  • Standardizing antibiotic protocols and patient risk stratification are essential for complication reduction.
Abstract

Keywords:
Bone cystanti-bacterial agentschildgrowth platerisk factorssurgical wound healing

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