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Updated: Jun 7, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Chemodivergent Approach to 1,2,3-Triazole-Fused Quinazolines
Roman S Tatevosian1, Gennadij V Latyshev1, Yury N Kotovshchikov1
1Chemistry Department, M. V. Lomonosov Moscow State University, Moscow 119991, Russia.
Abstract:
We have developed a convenient approach to the assembly of 1,2,3-triazole-fused quinazolines through the cyclization of 5-iodotriazoles bearing a pendant sulfonamide moiety. The C(sp2)-N bond formation proceeds efficiently as a base-promoted halogen substitution in the triazole ring. The rational choice of base and solvent enables the chemodivergent synthesis of either triazole-fused quinazolines or their dihydro derivatives. The potential applications of the target heterocycles were illustrated by their involvement in Rh-catalyzed denitrogenative amidation.
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