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Integrative Biology Approaches Uncover Plasticizers' Pro-Carcinogenic Role in Prostate Cancer via Molecular Docking

Jing Huang1, Yumei Huang2, Ying Huang3

  • 1Department of Pharmacy, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.

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Mutagenicity and Carcinogenicity

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Bioactivation and Tissue Toxicity

Bioactivation is a metabolic process that transforms less reactive substances into highly reactive metabolites, initiating tissue toxicity. This transformation can lead to various toxic effects, including carcinogenesis and teratogenesis. Reactive metabolites are classified into two main types: electrophiles and free radicals.Electrophiles are electron-deficient species and are produced primarily by the enzyme cytochrome P-450 during the metabolism of compounds containing carbon, nitrogen, or...
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Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
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Environmental pollutants like...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Convergence and divergence, and cross-talk between signaling pathways
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Toxicity Testing in Animals01:23

Toxicity Testing in Animals

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Protein Networks

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