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Safety and efficacy of a novel antimicrobial wound dressing compared with a standard dressing in diabetic foot ulcers
Gyan Chand1, Shudha Singh2, Rahul Kumar1
1Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Objective:
The aim of this study was to assess and compare the safety and efficacy of a novel antimicrobial wound dressing, VELVERT (Datt Mediproducts Pvt. Ltd., India), with AQUACEL Ag Foam dressing (Convatec, UK), a standard dressing for the treatment of diabetic foot ulcers (DFUs).
Method:
In this prospective, randomised, two-arm open-label study, patients with diabetes with stage 2/3 DFUs were enrolled at the Department of Endocrine Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, India. The patients were divided into two equal-sized groups: half receiving treatment with the novel dressing, and the remaining patients treated with the standard dressing. The total duration of the study was 28±1 days or complete wound closure, whichever was earlier.
Results:
A total of 100 patients took part in the study, with 50 patients in each group. On study completion, 14 patients in the novel dressing group and 11 patients in the standard dressing group exhibited complete wound healing. However, four patients in the standard dressing group did not show any improvement in healing. Moreover, in the standard dressing group, only 31.76% of the total wound area healed compared with 60.78% in the novel dressing group. Furthermore, the per-day rate of healing was 1.13% in the standard dressing group and 2.16% in the novel dressing group. Infection was the foremost impediment to the overall healing of these DFUs. On day 0, 50% of the patients in the standard dressing group and 80% in the novel dressing group were positive for microorganisms. However, by the end of the study, the percentage of patients with infection had reduced to 4.0% in the novel dressing group and to 18% in the standard dressing group, indicating the robust antimicrobial efficacy of the novel antimicrobial dressing.
Conclusion:
The findings of this study showed that the novel dressing, when compared to the standard dressing, demonstrated improved wound healing efficacy and higher antimicrobial activity.
