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Infantile tinea faciei caused by Trichophyton indotineae successfully treated with topical ketoconazole: A case
Chuong Nguyen Hoang1, Van Pham Thi Thanh2, Hai Tang Tuan3
1Institute of Biomedicine, Hue University of Medicine and Pharmacy, Hue University, Hue City 49000, Vietnam; Faculty of Fundamental Sciences and Basic Medical Sciences, Pham Ngoc Thach University of Medicine, Ho Chi Minh City 70000, Vietnam.
Background:
Dermatophyte infections are increasing worldwide, with shifts in the distribution of causative species. Trichophyton indotineae has gained attention due to its antifungal resistance. Infections caused by Trichophyton indotineae in infants are rarely reported.
Case Presentation:
We report a case of tinea faciei caused by Trichophyton indotineae in a 5-month-old Vietnamese infant, likely infected via maternal transmission. Fungal species identification was confirmed by ITS1-5.8S-ITS2 sequencing. Antifungal susceptibility testing revealed susceptibility to terbinafine (MIC = 0.0313 µg/mL). Sequence analysis of antifungal target genes showed wild-type SQLE and CYP51A, and a novel CYP51B substitution (Tyr444His). The child's lesions resolved after 4 weeks of treatment with 2% ketoconazole cream, with no recurrence at 3 months.
Conclusion:
This case highlights Trichophyton indotineae as an emerging dermatophyte capable of infecting infants. Further studies on antifungal management in pediatric patients are warranted.
Insights
A rare case of infant tinea faciei caused by the antifungal-resistant fungus Trichophyton indotineae is presented. The infant responded well to ketoconazole treatment, highlighting this emerging pathogen in pediatric dermatology.
Area of Science:
- Medical Mycology
- Pediatric Dermatology
- Infectious Diseases
Background:
- Dermatophyte infections are globally increasing, with notable shifts in causative species distribution.
- Trichophyton indotineae is emerging as a significant pathogen due to its antifungal resistance.
- Infant infections with Trichophyton indotineae are infrequently documented.
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