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Association Between Glyco-Lipid Seven-Factor Index, a Novel Composite Glyco-Lipid Index, and Periodontitis: A
Haoyu Su1, Kun Zhang1, Huijuan Zhang1
1College & Hospital of Stomatology, Anhui Medical University, Anhui Provincial Key Laboratory of Oral Diseases Research, Hefei 230032, China.
Background:
The glyco-lipid seven-factor index (GLM7) is a recently developed composite indicator comprising seven conventional biomarkers related to glycosphingolipid metabolism. Accumulating evidence suggests that GLM7 demonstrates favourable diagnostic performance in cardiovascular disease, diabetes mellitus, liver disease, malignancies, and multimorbidity. However, its potential relevance to oral health-related conditions has not yet been investigated.
Materials And Methods:
This cross-sectional study analysed data from 4008 participants enrolled in the National Health and Nutrition Examination Survey (NHANES) 2009 to 2014 cycles. GLM7 was defined as the exposure variable, while periodontitis served as the outcome of interest. Multivariable logistic regression models and restricted cubic spline analyses were employed to examine the association between GLM7 and periodontitis. In addition, subgroup and interaction analyses were conducted to assess the robustness of the findings.
Results:
After full adjustment for confounding variables, GLM7 was positively associated with periodontitis (OR = 1.19, 95% CI: 1.04-1.37). Subgroup analyses suggested that the association was more evident in individuals without hypertension, while restricted cubic spline analysis revealed an approximately linear relationship between GLM7 and periodontitis.
Conclusion:
An elevated GLM7 level was associated with a higher prevalence of periodontitis. As a composite index based on routinely measured glyco-lipid metabolic markers, GLM7 may have potential utility in identifying individuals with a higher likelihood of periodontitis, which broadens the scope of application of this emerging metabolic indicator.
