Related Experiment Video

Updated: Jun 7, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

Cardiovascular magnetic resonance-derived left atrial parameters for assessing diastolic dysfunction and prognosis in

Weiwei Liao1, Jianping Zhong1, Wenjian Tang1

  • 1Medical Imaging Center, Ganzhou Hospital-Nanfang Hospital, Southern Medical University (Ganzhou People's Hospital), Ganzhou, Jiangxi, China.

Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance
|June 5, 2026
PubMed

Insights

Cardiovascular magnetic resonance (CMR) left atrial (LA) parameters effectively diagnose diastolic dysfunction in hypertrophic cardiomyopathy (HCM). These LA parameters also predict heart failure and atrial fibrillation, aiding risk stratification.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Echocardiography is standard for assessing left ventricular diastolic dysfunction (LVDD) in hypertrophic cardiomyopathy (HCM).
  • Cardiovascular magnetic resonance (CMR) lacks guideline-recommended valvular hemodynamic parameters for LVDD assessment.
  • This study explores the diagnostic and prognostic utility of CMR-derived left atrial (LA) parameters for guideline-defined LVDD in HCM.

Purpose of the Study:

  • To evaluate the diagnostic value of CMR LA parameters for guideline-defined LVDD in HCM patients.
  • To assess the prognostic significance of CMR LA parameters for adverse cardiovascular events in HCM.
  • To compare the efficacy of LA parameters versus traditional LV indices in diagnosing elevated left atrial pressure (LAP).

Main Methods:

  • A dual-center study involving 248 HCM patients and 70 controls, all undergoing echocardiography and CMR.
  • Patients were classified based on echocardiographic guidelines for normal or elevated left atrial pressure (LAP).
  • CMR-derived volumetric and feature-tracking (FT) strain analyses quantified left heart function, focusing on LA parameters.

Main Results:

  • HCM patients exhibited impaired LA reservoir, conduit, and booster pump strains compared to controls, worsening with LVDD progression.
  • LA parameters, particularly LA reservoir strain (εs), demonstrated superior diagnostic ability for elevated LAP compared to LV indices (AUC=0.903).
  • LA parameters (εs, LAVImin) and LV-LGE burden independently predicted heart failure events, while εs also predicted atrial fibrillation, outperforming the HCM-AF score.

Conclusions:

  • CMR-derived LA parameters are sensitive indicators of LVDD with elevated LAP in HCM.
  • These LA parameters offer significant clinical value for risk stratification and prognostic assessment in HCM patients.
  • CMR LA parameters enhance the comprehensive evaluation of diastolic function and cardiovascular risk in HCM.
Abstract

Keywords:
CMRCMR-FThypertrophic cardiomyopathyleft atrialleft atrial pressureleft ventricular diastolic dysfunction

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