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Updated: Jun 7, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
05:31

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

Eclampsia despite magnesium sulfate prophylaxis.

Anne M Ambia1, Sara I Jones1, Rachel C Schell1

  • 1Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine. University of Texas Southwestern Medical Center, Dallas, Texas.

American Journal of Obstetrics & Gynecology MFM
|June 5, 2026
PubMed
Summary
This summary is machine-generated.

Despite magnesium sulfate prophylaxis, some patients develop eclampsia, leading to severe maternal morbidity and increased neonatal intensive care unit admissions. This highlights the need for continued vigilance and management strategies for eclampsia despite treatment.

Keywords:
EclampsiaMagnesium sulfateSeizureendotracheal intubationintensive care unitmaternal morbidityplacental abruption

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Last Updated: Jun 7, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
05:31

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Neurology

Background:

  • Magnesium sulfate is a primary treatment for preeclampsia with severe features and eclampsia prevention.
  • Limited data exists on maternal and perinatal outcomes for patients experiencing eclampsia despite magnesium sulfate prophylaxis.

Purpose of the Study:

  • To describe the maternal and perinatal consequences in patients who develop eclampsia despite receiving magnesium sulfate therapy.

Main Methods:

  • A 13-year retrospective study of eclampsia cases at a single institution.
  • Diagnosis of eclampsia followed American College of Obstetricians and Gynecologists criteria.
  • Maternal and perinatal outcomes were reviewed by Maternal-Fetal Medicine specialists.

Main Results:

  • Twenty-six (21%) of 123 eclampsia cases occurred despite magnesium sulfate prophylaxis, with 65% having therapeutic serum magnesium levels.
  • Maternal morbidity included multiple seizures (38%), endotracheal intubation (31%), HELLP syndrome (23%), and ICU admission (19%).
  • Infants born to mothers with eclampsia despite prophylaxis had higher neonatal intensive care unit admission rates (p=0.02).

Conclusions:

  • While magnesium sulfate is effective, eclampsia can occur despite treatment, resulting in significant maternal morbidity.
  • Patients experiencing eclampsia despite magnesium sulfate prophylaxis showed increased rates of severe maternal complications.
  • These findings underscore the importance of monitoring and managing patients at risk for breakthrough eclamptic seizures.