Related Experiment Video
Updated: Jun 7, 2026
Iridium(III) Luminescent Probe for Detection of the Malarial Protein Biomarker Histidine Rich Protein-II
Published on: July 7, 2015
DNA-Binding Properties of Iridium(III) Complexes Encompassing Design, Function and Biophysical Assessments
Ibrahim S Alkhaibari1,2, Niklaas J Buurma1, Simon J A Pope1
1School of Chemistry, Cardiff University, Cardiff, UK.
None:
The increasingly diverse biological applications of iridium(III) complexes, from luminescent cellular imaging agents to therapeutic and prospective theranostics, has been enabled by a combination of imaginative ligand design and tunable (photo)physical properties. Within this biological context, it is crucial to understand how molecular probes interact with biological substrates and macromolecules. This review focuses upon the structural diversity of DNA-binding metal complexes based upon iridium(III), the general workflow used to interrogate these interactions with DNA, and critically analyses the relationship between complex structure and functionality.
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