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Updated: Jun 7, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Androgen loss backfires: Brain gate for tumor immunity
1The First Clinical Medical College of Lanzhou University, Lanzhou 730000, PR China; Institute of Cancer Neuroscience, Medical Frontier Innovation Research Center, The First Hospital of Lanzhou University, the First Clinical Medical College of Lanzhou University, Lanzhou 730000, PR China.
Abstract:
Androgen deprivation is assumed to boost antitumor immunity-but Lee et al. overturn this logic in glioblastoma, showing that androgen loss activates a microglial inflammasome-hypothalamic-pituitary-adrenal axis cascade that elevates glucocorticoids and attenuates T cell function. The study reveals how organ context reverses endocrine control of tumor immunity.
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