Related Experiment Video

Updated: Jun 7, 2026

Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens
09:19

Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens

Published on: December 9, 2022

Pseudomyxoma peritonei and the microbiome: Emerging observations and unanswered questions

Jessica M Grant1, Cui Tu1, Kate E Roberts2

  • 1Frazer Institute, Faculty of Health, Medicine and Behavioral Sciences, The University of Queensland, Woolloongabba, Queensland 4102, Australia.

Trends in Cancer
|June 5, 2026
PubMed

Insights

Pseudomyxoma peritonei, a rare appendiceal cancer, involves mucus-secreting cells and a potential microbial link. Spatial multiomics may reveal disease mechanisms and guide new treatments for this complex condition.

Area of Science:

  • Oncology
  • Microbiology
  • Gastroenterology

Background:

  • Pseudomyxoma peritonei is a rare appendiceal cancer with mucus-secreting tumor cells.
  • A microbial association is suggested but not well understood.
  • Understanding this link is crucial for disease progression and treatment.

Purpose of the Study:

  • To synthesize current knowledge on the interplay between microbial communities, mucin biology, and pseudomyxoma peritonei.
  • To identify key research challenges in this field.
  • To explore the potential of spatial multiomics in elucidating disease mechanisms and therapeutic strategies.

Main Methods:

  • Literature review and synthesis of existing research.
  • Discussion of microbial roles in mucin biology and cancer.
  • Exploration of spatial multiomics as a novel investigative approach.

Main Results:

  • The relationship between microbes, mucin, and tumor behavior in pseudomyxoma peritonei is complex and requires further investigation.
  • Current research faces challenges in integrating multi-disciplinary data.
  • Spatial multiomics offers a promising avenue for detailed mechanistic insights.

Conclusions:

  • Further research is needed to clarify the significance of microbial communities in pseudomyxoma peritonei.
  • Spatial multiomics holds potential for advancing our understanding and developing targeted therapies.
  • Integrating microbial and host factors is key to addressing this rare appendiceal cancer.
Keywords:
appendiceal cancershost–microbe interactionspseudomyxoma peritoneispatial profilingtherapeutic opportunities

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