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Adhesion

Adhesion

Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow glass...

Adherens Junctions

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...

Cell Adhesion in Plants

Cell Adhesion in Plants

Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose, and...

Intracellular Signaling Affects Focal Adhesions

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...

Tension Response at Adherens Junctions

Tension Response at Adherens Junctions

The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin homology) domains...

Cohesion

Cohesion

Cohesion is the attraction between molecules of the same type, such as water molecules. Water molecules have an overall neutral charge but are polar molecule. An oxygen atom in one water molecule has a partial negative charge that can bind to a hydrogen atom with a partial positive charge in a second water molecule, forming a hydrogen bond. Each water molecule can form up to four hydrogen bonds with other water molecules. Hydrogen bonds are responsible for water's cohesive nature.
On a surface,...

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Related Experiment Video

Updated: Jun 7, 2026

Adhesion Frequency Assay for In Situ Kinetics Analysis of Cross-Junctional Molecular Interactions at the Cell-Cell Interface

Adhesion Frequency Assay for In Situ Kinetics Analysis of Cross-Junctional Molecular Interactions at the Cell-Cell Interface

Published on: November 2, 2011

Adhesion-derived condensates control component availability to regulate adhesion dynamics.

Michal Dibus^1,2, Megan R Chastney^3,4, Giray Enkavi⁵

¹Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland. michal.dibus@utu.fi.

Nature Communications

|June 5, 2026

Summary

This summary is machine-generated.

Tensin 1 (TNS1) forms reversible condensates to regulate cell adhesion dynamics. These TNS1 condensates act as reservoirs for adhesion proteins, influencing cell migration and adhesion turnover.

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Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

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Last Updated: Jun 7, 2026

Adhesion Frequency Assay for In Situ Kinetics Analysis of Cross-Junctional Molecular Interactions at the Cell-Cell Interface

Adhesion Frequency Assay for In Situ Kinetics Analysis of Cross-Junctional Molecular Interactions at the Cell-Cell Interface

Published on: November 2, 2011

Dendrimer-based Uneven Nanopatterns to Locally Control Surface Adhesiveness: A Method to Direct Chondrogenic Differentiation

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Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

Area of Science:

Cell biology
Biochemistry
Biophysics

Background:

Integrin adhesion complexes are crucial for cell-matrix interactions, regulating cell adhesion, migration, and invasion.
Liquid-liquid phase separation is increasingly implicated in cellular processes, but its role in adhesion component regulation is unclear.

Purpose of the Study:

To investigate the formation and function of tensin 1 (TNS1) condensates in regulating cell adhesion dynamics.
To elucidate the role of TNS1 condensation in cell migration and adhesion turnover.

Main Methods:

Immunofluorescence microscopy to visualize TNS1 condensates.
Biochemical assays to analyze protein availability and phosphorylation.
Live-cell imaging to study adhesion dynamics and cell migration.
Analysis of intrinsically disordered regions for condensation properties.

Main Results:

Endogenous TNS1 forms reversible condensates during focal adhesion disassembly and limited integrin engagement.
TNS1 condensates serve as reservoirs for unphosphorylated adhesion proteins.
The intrinsically disordered region of TNS1 governs its condensation and biophysical properties.
Phosphorylation negatively regulates TNS1 condensate assembly upon kinase activation.
TNS1 condensation influences adhesion dynamics and cell migration, establishing a feedback loop for adhesion turnover.

Conclusions:

Tensin 1 condensation is a key mechanism for regulating the availability of adhesion proteins.
TNS1 condensates play a critical role in modulating cell adhesion dynamics and migration.
A feedback loop involving TNS1 condensation acutely regulates kinase-mediated adhesion turnover upon integrin activation.