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Updated: Jun 7, 2026

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes
Published on: May 31, 2011
Structural motif search across the protein universe with Folddisco
Hyunbin Kim1,2, Rachel Seongeun Kim1,2, Milot Mirdita2,3,4
1Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea.
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Detecting similar protein structural motifs in large structure collections is computationally expensive. We developed Folddisco, a fast structural motif search tool that uses an index of position-independent geometric features, including side-chain orientation, combined with a rarity-based scoring system. Folddisco is 20-fold faster in querying and fourfold more storage-efficient than existing methods while improving accuracy. Folddisco is freely available online ( https://folddisco.foldseek.com ), along with a webserver ( https://search.foldseek.com/folddisco ).
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