Multiple leiomyosarcoma of great saphenous vein with lung metastasis

There are very few publications on unplanned excisions of great saphenous vein leiomyosarcomas (GSV-LMS). We describe a 64-year-old female patient with multiple leiomyosarcoma in the great saphenous vein (a total of 13 lesions) with lung metastasis. The patient was initially misdiagnosed and underwent a repeat surgical intervention. During the follow-up, a pulmonary nodule showed progressive enlargement, and the patient underwent pulmonary surgery. confirmed it to be a metastatic lesion. While some literature has documented this disease, the multidisciplinary treatment has not been emphasized, and the high incidence of lung metastasis has been overlooked. This is crucial importance of early identification and precise evaluation of lung metastasis. Given the paucity of cases, our case contributes valuable insights into the treatment approach necessary for optimal outcomes in GSV-LMS with lung metastasis. Multidisciplinary and aggressive treatment, under the guidance of the thoracic surgeon, remain paramount to improving survival in this rare malignancy with metastasis.