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Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients
07:42

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Published on: February 7, 2021

"Outstanding" ADC Candidates Emerge for SCLC, Other Cancers

    Cancer Discovery
    |June 5, 2026
    PubMed

    Insights

    New antibody-drug conjugates show promising results for small cell lung cancer treatment. Early studies reveal high response rates for CD56, DLL-3, and B7-H3 targeting agents, with potential in other cancers too.

    Area of Science:

    • Oncology
    • Pharmacology
    • Biotechnology

    Background:

    • Small cell lung cancer (SCLC) has limited treatment options.
    • Antibody-drug conjugates (ADCs) represent a novel therapeutic strategy.
    • Targeted therapies are crucial for improving cancer treatment outcomes.

    Purpose of the Study:

    • To evaluate the efficacy and safety of novel ADC candidates in early-phase clinical trials.
    • To explore the potential of ADCs targeting CD56, DLL-3, and B7-H3 in SCLC.
    • To assess the activity of HER2-targeting trastuzumab brexucan in platinum-resistant ovarian cancer.

    Main Methods:

    • Phase I clinical studies of DXC006 (anti-CD56), BL-M14D1 (anti-DLL-3), and SYS6043 (anti-B7-H3).
    • Phase II study of trastuzumab brexucan (anti-HER2).
    • Assessment of response rates and activity across different tumor types.

    Main Results:

    • Robust response rates observed with DXC006, BL-M14D1, and SYS6043 in SCLC patients.
    • SYS6043 demonstrated activity in ovarian and breast cancers.
    • Trastuzumab brexucan showed strong efficacy in platinum-resistant ovarian cancer.

    Conclusions:

    • Antibody-drug conjugates targeting CD56, DLL-3, and B7-H3 show significant promise for SCLC treatment.
    • SYS6043 may have broader applications beyond SCLC.
    • Trastuzumab brexucan is a potential new therapy for platinum-resistant ovarian cancer.

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