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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Single Molecule Eu2+/3+ Complex Platform for Optical and Magnetic Resonance Imaging In Vivo.

Carter B Rodgers1, Morgan P Deal2, Leah C Garman1

  • 1Department of Chemistry, University of Wisconsin, 1101 University Avenue, Madison, Wisconsin 53706, United States.

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Researchers developed novel lanthanide complexes for dual magnetic resonance and optical imaging. These redox-switchable europium (Eu2+/3+) chelates offer multimodal imaging capabilities from a single agent, advancing biological imaging techniques.

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Area of Science:

  • Coordination Chemistry
  • Materials Science
  • Biomedical Imaging

Background:

  • Lanthanide complexes are valuable for biological imaging due to stability, relaxivity, and luminescence.
  • Current multimodal strategies often require lanthanide ion exchange, complicating imaging.
  • The redox chemistry of Europium (Eu2+/3+) offers a unique opportunity for single-agent multimodal imaging.

Purpose of the Study:

  • To demonstrate multimodal imaging using a single chelate scaffold by exploiting the Eu2+/3+ redox pair.
  • To design and synthesize novel polypyridine-containing macrocyclic ligands capable of coordinating both Eu2+ and Eu3+.
  • To evaluate the imaging performance of these complexes for both magnetic resonance imaging (MRI) and optical imaging.

Main Methods:

  • Synthesis of acetamide-functionalized, polypyridine-containing 18-membered macrocyclic ligands.
  • Coordination of Eu2+ and Eu3+ ions to the synthesized ligands.
  • Characterization using X-ray crystallography, cyclic voltammetry, electron paramagnetic resonance (EPR) spectroscopy, and photophysical measurements.
  • Evaluation of relaxometric properties for MRI and luminescence for optical imaging.
  • In vitro and in vivo (murine xenograft tumor model) imaging studies.

Main Results:

  • Eu2+ complexes exhibited relaxometric properties comparable to clinical gadolinium (Gd3+) MRI contrast agents.
  • Oxidized Eu3+ complexes showed luminescence with quantum yields between 1.3% and 13.9%.
  • In situ sensitization with a Cherenkov-emitting radionuclide enabled efficient Eu3+ emission.
  • A single complex demonstrated high signal-to-noise ratio in MRI and detectable optical signals at low concentrations (5 nmol).
  • Sequential MRI and optical imaging were successfully performed in vivo after a single administration.

Conclusions:

  • Redox-switchable Europium complexes enable multimodal imaging (MRI and optical) within a single chelate.
  • These novel complexes offer comparable MRI performance to existing agents and viable optical imaging capabilities.
  • The developed strategy presents a promising platform for advanced sequential biological imaging applications.