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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation
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Timeline of Functional Recovery Following Hand and Upper-Extremity Transplantation.

Isaac Mordukhovich1, Connor Roncagli1, Natalie Hoffner1

  • 1Department of Plastic Surgery, Cleveland Clinic, Cleveland, OH; Case Western Reserve University School of Medicine, Cleveland, OH.

The Journal of Hand Surgery
|June 6, 2026
PubMed
Summary
This summary is machine-generated.

Hand and upper-extremity transplantation (HUET) outcomes improve over 10 years, with distal transplants showing better recovery. Bilateral HUETs yield superior psychosocial results compared to unilateral procedures.

Keywords:
Hand transplantreconstructive plastic surgeryvascularized composite allotransplant

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Area of Science:

  • * Transplantation medicine
  • * Regenerative medicine
  • * Orthopedic surgery

Background:

  • * Functional recovery following hand and upper-extremity transplantation (HUET) is not fully understood.
  • * Quantifying motor and psychosocial outcomes in the first decade post-HUET is crucial for patient management and surgical planning.

Purpose of the Study:

  • * To systematically review and analyze motor and psychosocial recovery trends in HUET recipients over 10 years post-transplantation.
  • * To investigate the influence of transplant level (proximal vs. distal) and laterality (unilateral vs. bilateral) on functional outcomes.

Main Methods:

  • * Systematic review of PubMed, Embase, Cochrane, and Medline databases, including 118 articles from 2104 records.
  • * Categorization of HUETs into proximal and distal based on forearm location.
  • * Assessment of outcomes using Semmes-Weinstein Monofilament (SWMF) test, grip strength, Kapandji score, total active range of motions (TAROMs), SF-36, DASH, and HTSS, analyzed by postoperative year (POY).

Main Results:

  • * Distal HUETs showed improved SWMF and better power grip recovery compared to proximal HUETs.
  • * While finger TAROMs stabilized post-POY1, lateral grip, Kapandji scores, HTSS, and SWMF demonstrated sustained improvements over the decade, particularly for distal transplants.
  • * Bilateral HUETs reported significantly better psychosocial outcomes (SF-36 scores) than unilateral HUETs, with no difference in DASH scores.

Conclusions:

  • * Transplant level significantly impacts power grip and HTSS recovery, with distal HUETs generally achieving better results.
  • * Motor function (power grip, lateral grip, SWMF) and psychosocial well-being (HTSS, SF-36) show improvement in the first decade post-HUET, with variations based on transplant location and laterality.
  • * Bilateral HUETs offer advantages in psychosocial recovery, highlighting the importance of transplant strategy in optimizing functional outcomes.