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Related Concept Videos

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Aneurysm III: Interprofessional Care

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Related Experiment Videos

Retinal Arterial Macroaneurysms: Clinical Features, Management, and Outcomes.

Charles Zhang1, Katherine E Bowers2, Saara Khan2

  • 1Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida.

Ophthalmology. Retina
|June 6, 2026
PubMed
Summary
This summary is machine-generated.

Retinal arterial macroaneurysms (RAM) often resolve spontaneously. While observation is common, early treatment may accelerate RAM resolution in severe cases.

Keywords:
Antivascular endothelial growth factorMacular hemorrhageRetinal arterial macroaneurysmRetrospective cohort studyVisual acuity

Related Experiment Videos

Area of Science:

  • Ophthalmology
  • Retinal Vascular Diseases
  • Medical Retina

Background:

  • Retinal arterial macroaneurysms (RAM) are dilations of retinal arteries, often associated with hypertension.
  • Management strategies range from observation to various treatment modalities.
  • Understanding outcomes is crucial for guiding clinical decisions.

Purpose of the Study:

  • To compare baseline characteristics, management, and long-term outcomes of eyes with RAM.
  • To evaluate outcomes in contemporary cohorts managed with observation versus early treatment.

Main Methods:

  • Retrospective cohort study of adult patients diagnosed with RAM.
  • Data included demographics, ocular findings, OCT imaging, treatments, and visual acuity.
  • Statistical analysis used t-tests, Wilcoxon signed-rank tests, chi-square, and Fisher's exact tests.

Main Results:

  • 161 eyes (156 patients) were analyzed; 68% observed, 32% treated.
  • The treatment cohort had worse initial BCVA and more macula hemorrhage (P<0.0024).
  • RAM resolution occurred in 100% of eyes in both groups; treatment expedited resolution (362 vs 536 days, P=0.0170).

Conclusions:

  • Most RAM cases improve spontaneously.
  • Selective early treatment may be beneficial for eyes with severe initial presentations.
  • Observation is a viable strategy, but treatment can accelerate resolution.