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Delivering living medicines with polysaccharide derivatives for disease treatment
Qianying Huang1, Binglin Ye2, Huang Yang3
1Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, PR China; Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou, Zhejiang 310009, PR China; Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, Hangzhou, Zhejiang 310009, PR China; Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, PR China; ZJU-Pujian Research&Development Center of Medical Artificial Intelligence for Hepatobiliary and Pancreatic Disease, Hangzhou, Zhejiang 310058, PR China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310058, PR China; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, PR China; Zhejiang Provincial Clinical Research Center for CANCER, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, PR China.
Abstract:
Living medicines represent a revolutionary approach to modern therapeutics, but their effective delivery and in vivo functional maintenance pose significant challenges. Polysaccharide derivatives have emerged as ideal materials for the construction of advanced delivery systems owing to their exceptional biocompatibility, ECM-mimetic microenvironment and mechanically tunable properties. This review systematically analyses the applications of polysaccharide derivatives in live medicine delivery, elucidating their chemical modification strategies, design principles of delivery systems, and disease-specific applications. We focused on the latest advances in polysaccharide-based delivery systems for inflammatory bowel disease, cancer, central nervous system disorders, and tissue regeneration, while addressing the challenges in clinical translation and future directions. In summary, this review thus bridges fundamental material design with translational goals, offering guidance for developing effective polysaccharide-based delivery systems for living medicines.
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