Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Adrenergic Agonists: Therapeutic Uses01:30

Adrenergic Agonists: Therapeutic Uses

Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and anaphylaxis:...
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Allergen Immunotherapy and Possible Clinical Remission: Toward a Disease-Modifying Paradigm in Allergic Disorders.

Biomedicines·2026
Same author

Real-world effectiveness of tezepelumab on clinical remission and small airway dysfunction in severe asthma: a 52-week prospective study.

Expert opinion on biological therapy·2026
Same author

Characterizing the nasal microbiome using a nasal allergen challenge model.

The Journal of allergy and clinical immunology·2026
Same author

Is Asthma Remission a New Achievable Goal? A Review of the Current Drug-Related Evidence and Predictors.

Allergy·2026
Same author

Low risk of ocular toxicity following topical ocular administration of epinephrine nasal spray: implications for unintentional exposure.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology·2026
Same author

Clinical symptoms and biomarkers of cat allergen-induced allergic rhinitis using the nasal allergen challenge model.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026

Related Experiment Video

Updated: Jun 8, 2026

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Anaphylaxis and Epinephrine Use in Pregnancy.

Luciana Kase Tanno1, Anne K Ellis2, Lubnaa Hossenbaccus3

  • 1Division of Allergy, Department of Pulmonology, Allergy and Thoracic Oncology, University Hospital of Montpellier, Montpellier, France; Desbrest Institute of Epidemiology and Public Health, UMR 1318 University of Montpellier-INSERM, Montpellier, France; WHO Collaborating Centre on Scientific Classification Support, Montpellier, France.

The Journal of Allergy and Clinical Immunology. in Practice
|June 6, 2026
PubMed
Summary

Anaphylaxis in pregnancy is rare but dangerous. Prompt epinephrine is crucial for maternal and fetal safety, requiring better interdisciplinary care and prevention strategies.

Keywords:
AnaphylaxisCesarean deliveryDeliveryDiagnosisEpidemiologyEpinephrineManagementPerioperative anaphylaxisPregnancyPreventionTreatment

More Related Videos

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Related Experiment Videos

Last Updated: Jun 8, 2026

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Area of Science:

  • Obstetrics and Gynecology
  • Allergy and Immunology
  • Epidemiology

Background:

  • Anaphylaxis during pregnancy presents unique diagnostic and management challenges due to physiological changes.
  • Pregnancy-specific factors can complicate anaphylaxis recognition, treatment, and prevention, leading to adverse outcomes.

Purpose of the Study:

  • To provide a multidisciplinary review of anaphylaxis in pregnancy, covering epidemiology, pathophysiology, diagnosis, management, and outcomes.
  • To synthesize evidence and offer a practical framework for health professionals to optimize care and maternal-fetal safety.

Main Methods:

  • Multidisciplinary review of current evidence by experts in allergy-immunology, obstetrics, anesthesiology, and epidemiology.
  • Synthesis of data on anaphylaxis triggers, diagnostic challenges, management protocols, and maternal/fetal outcomes.

Main Results:

  • Gestational changes can mask classic anaphylaxis symptoms, complicating diagnosis.
  • Intramuscular epinephrine is safe and essential as first-line treatment for anaphylaxis in pregnancy.
  • Timely intervention significantly improves maternal and fetal outcomes compared to delayed treatment.

Conclusions:

  • Increased awareness and structured interdisciplinary collaboration are vital for managing anaphylaxis in pregnancy.
  • Integrating prevention strategies into obstetric and allergy care is crucial for reducing adverse events.
  • Evidence-based guidelines are needed to support health professionals in optimizing diagnosis, management, and safety.