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The Covid-19 pandemic as an inflection point in US mortality trends from hematologic and circulatory system diseases:

Amirali Koohi Bachemir1, Zhenshan Sun2, Melika Safari1

  • 1Department of Cellular and Molecular Biology, TMS.C, Islamic Azad University, Tehran, Iran.

BMC Public Health
|June 6, 2026
PubMed

Insights

The COVID-19 pandemic increased mortality rates for hematologic-immune and circulatory diseases in the US. Vulnerable groups, including older adults and younger males, were disproportionately affected, necessitating ongoing surveillance.

Area of Science:

  • Public Health
  • Epidemiology
  • Biostatistics

Background:

  • The COVID-19 pandemic significantly disrupted healthcare systems globally.
  • Potential impacts on mortality trends for hematologic-immune disorders (D50-D89) and circulatory system diseases (I00-I99) require investigation.

Purpose of the Study:

  • To evaluate US mortality trends from 2010 to 2023.
  • To assess potential pandemic-related shifts in mortality for specific disease categories.

Main Methods:

  • Utilized CDC WONDER mortality data from 2010-2023.
  • Employed spline regression modeling to quantify trend shifts.
  • Analyzed age-adjusted and sex/age-stratified mortality rates.

Main Results:

  • Post-2019 mortality showed significant increases in D50-D89 and I00-I99 diseases.
  • Notable increases observed in older adults and younger males.
  • Specific findings include ~2.6% annual increase in D50-D89 for females ≥65 and ~4.5% for males 15-34.

Conclusions:

  • The COVID-19 pandemic has had a lasting impact on mortality from hematologic and circulatory diseases.
  • Continued monitoring of mortality trends in vulnerable populations is crucial.
  • Findings underscore the need for public health interventions targeting these disease categories.
Abstract

Keywords:
Blood disordersCOVID-19 pandemicCirculatory System disordersHematologic disorders

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