Related Experiment Video
Updated: Jun 8, 2026

Chronic Social Defeat Stress in Early Adolescent Male Mice
Published on: January 24, 2025
Social environmental risk factors for persistent self-harm in early-to-middle adolescence: data from the Tokyo Teen
Riki Tanaka1,2, Atsushi Nishida3, Daiki Nagaoka1
1Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Background:
While most adolescent self-harm (SH) is transient, a substantial minority of adolescents repeat and continue it, requiring intensive care. Although social environmental factors play an important role in adolescent psychological development, little is known about their role in the persistence of SH. Moreover, few studies have focused specifically on early adolescence, when SH often begins, hospital presentations after SH increase sharply, and many preventive programs typically commence. We aimed to identify social environmental risk factors at age 12 that predict the persistence of SH through ages 14 and 16 in a population-based cohort.
Methods:
We used data from the Tokyo Teen Cohort study (N = 1501). The experience of SH was self-reported at three timepoints (12, 14 and 16 years of age), and categorized as none, transient (one timepoint), or persistent (≥ 2 timepoints). Potential risk factors were assessed at age 12, including family related factors, school and peer related factors, sociodemographic and developmental characteristics, and psychopathological experiences. Multivariable and multinomial logistic regression analyses were conducted to examine the associations of potential risk factors with transient and persistent SH.
Results:
Of the 1501 participants 195 (13.0%) experienced transient SH and 53 (3.5%) experienced persistent SH. In fully adjusted models, maternal depressive/anxious symptoms and female sex predicted persistent SH (maternal depressive/anxious symptoms: OR 1.47, 95% CI 1.13-1.92, female: OR 4.74, 95% CI 2.18-10.29), whereas companionship with mother predicted lower likelihood (OR 0.50, 95% CI 0.28-0.89). Depressive symptoms and psychotic experiences (PEs) predicted both transient (depressive symptoms: OR 1.77, 95% CI 1.50-2.10, PEs: OR 1.57, 95% CI 1.36-1.82) and persistent SH (depressive symptoms: OR 2.03, 95% CI 1.55-2.66, PEs: OR 1.89, 95% CI 1.48-2.41).
Conclusions:
Maternal depressive/anxious symptoms were the risk factor of persistent SH and companionship with mother was protective against persistence even after adjustment for other factors. Care for maternal depressive/anxious symptoms and support for mother-child relationships would be required to prevent the persistence of SH, in addition to the care for children's depressive symptoms and PEs.
Related Concept Videos
Conduct Disorder
Sources of Self-Esteem I: Family Experience
Erikson's Theory on Socioemotional Development during Adolescence
Self-Evaluation: Self-Enhancement and Self-Verification
Psychological and Sociocultural Causes of Schizophrenia
Bullying

