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Updated: Jun 8, 2026

Lipid Bilayer Vesicle Generation Using Microfluidic Jetting
Published on: February 21, 2014
Soft-Lubrication Drainage and Rupture in Particle-Driven Vesicles
Yuan-Nan Young1, Bryan Quaife2, Herve Nganguia3
1New Jersey Institute of Technology, Department of Mathematical Sciences, Newark, New Jersey 07102, USA.
Abstract:
The deformation and rupture of a lipid vesicle due to the forced normal approach of an inclusion are essential for optimizing the design of magnetic giant unilamellar vesicles (GUV) [Malik et al., Nanoscale 17, 13720 (2025)NANOHL2040-336410.1039/D5NR00942A], with implications for active colloid-membrane interactions and cellular-scale chemical delivery. Here, we investigate vesicles propelled by a force-driven rigid inclusion and reveal a robust elastohydrodynamic mechanism: the inclusion outpaces the vesicle, sustaining a thinning film that drains symmetrically and self-similarly, largely independent of the initial shape. For soft membranes and small inclusions, the coupling drives a monotonic tension increase that can exceed the lysis tension. Evaluating the maximal tension over a delivery distance, we map an operating window in a vesicle reduced area and size relative to the inclusion.
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