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Clinicopathologic spectrum and outcomes of primary ovarian lymphoma: a retrospective case series
Ying Shan1, Xiaoling Chen2, Dahui Li3
1Department of Haematology, The Affiliated People's Hospital of Ningbo University, Ningbo, Zhejiang, China.
Abstract:
Primary ovarian lymphoma (POL) is rare and often presents as an adnexal mass, creating diagnostic and management challenges. We performed a retrospective cohort study of 13 women diagnosed with POL between January 2018 and December 2023. Median age was 44 years (range 13-69), with 69.2% being premenopausal. LDH was elevated in 9/13 (69.2%) and CA-125 in 8/10 (80.0%) while CEA and CA19-9 were negative. Histology was heterogeneous: diffuse large B-cell lymphoma (DLBCL, 46.2%), extranodal NK/T-cell lymphoma (23.1%), Burkitt lymphoma (15.4%), marginal zone lymphoma (7.7%), and follicular lymphoma (7.7%). Median follow-up was 28 months (range 0.5-84). Three deaths occurred, all in patients without timely systemic therapy. Estimated 5-year OS was approximately 76.9% (95% CI, 57.1%-100%). In this contemporary POL series, clinicopathologic heterogeneity was prominent, and laboratory profiles frequently overlapped with ovarian malignancy work-up. Outcomes may be favorable among patients receiving timely, subtype-appropriate systemic treatment.