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Related Concept Videos

Fast Reactions01:27

Fast Reactions

Fast reactions occurring in times shorter than the time needed to mix reactants pose a unique challenge for investigation. In a liquid-phase continuous-flow system, reactants A and B are swiftly pushed into the mixing chamber, where mixing occurs within 1 ms. The reaction mixture then flows through an observation tube, and one measures light absorption to determine species concentrations at various points of the tube. This method is most appropriate when relatively large volumes of reactants...
Measuring Reaction Rates03:09

Measuring Reaction Rates

Polarimetry finds application in chemical kinetics to measure the concentration and reaction kinetics of optically active substances during a chemical reaction. Optically active substances have the capability of rotating the plane of polarization of linearly polarized light passing through them—a feature called optical rotation. Optical activity is attributed to the molecular structure of substances. Normal monochromatic light is unpolarized and possesses oscillations of the electrical field in...
Applications of IR Spectroscopy: Overview01:11

Applications of IR Spectroscopy: Overview

The non-destructive nature and ability to provide valuable chemical information make IR spectroscopy a versatile technique with broad applications in various scientific and industrial fields. IR spectroscopy is commonly used to identify and characterize organic and inorganic compounds. It provides information about the functional groups present in a molecule and the bonding between atoms. This helps in the structural elucidation of compounds during organic synthesis, pharmaceutical research,...
IR Spectroscopy: Molecular Vibration Overview01:24

IR Spectroscopy: Molecular Vibration Overview

When Infrared (IR) radiation passes through a covalently bonded molecule, the bonds transition from lower to higher vibrational levels. The fundamental vibrational motions that result in infrared absorption can be classified as stretching or bending vibrations.
Stretching vibrations are vibrational motions that occur along the bond line, changing the bond length or distance between two bonded atoms. They are further distinguished as symmetric or asymmetric. In symmetric stretching, the...
Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
Atomic Absorption Spectroscopy: Atomization Methods01:25

Atomic Absorption Spectroscopy: Atomization Methods

Atomic Absorption Spectroscopy (AAS) atomizes samples through flame atomization or electrothermal atomization. Flame atomization typically involves a nebulizer and spray chamber assembly to combine the sample with a fuel–oxidant mixture, creating a fine aerosol mist that enters a burner. Typically, the fuel and oxidant are combined in an approximately stoichiometric ratio. However, for atoms that are easily oxidized, a fuel-rich mixture may be more advantageous. Only about 5% of the aerosol...

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Related Experiment Video

Updated: Jun 9, 2026

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example
09:56

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example

Published on: November 18, 2015

Online IR spectroscopic quantification and reaction process analysis in continuous flow system.

Shiji Peng1, Qiyue Xu1, Jiong Ding1

  • 1Institute of Thermal Analysis Technology and Instrumentation, China Jiliang University, Hangzhou 310018, China.

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
|June 7, 2026
PubMed
Summary

This study introduces a new method for real-time chemical analysis in continuous flow reactors using FTIR spectroscopy and dynamic flow control. This approach enhances analytical efficiency for reaction monitoring and process optimization.

Keywords:
Concentration quantificationContinuous flow reactionInfrared spectroscopyOne-dimensional convolutional neural networkReaction optimization

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Last Updated: Jun 9, 2026

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example
09:56

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example

Published on: November 18, 2015

A Modular Microfluidic Technology for Systematic Studies of Colloidal Semiconductor Nanocrystals
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A Modular Microfluidic Technology for Systematic Studies of Colloidal Semiconductor Nanocrystals

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Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
08:24

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling

Published on: November 11, 2008

Area of Science:

  • Chemical Engineering
  • Analytical Chemistry
  • Spectroscopy

Background:

  • Continuous flow synthesis offers superior control and efficiency in chemical reactions.
  • Current methods for quantifying components in flow systems require extensive offline calibration, limiting analytical efficiency.
  • Real-time monitoring and rapid analysis are crucial for optimizing continuous flow processes.

Purpose of the Study:

  • To develop a rapid and continuous quantitative analysis method for continuous flow reaction systems.
  • To establish a real-time monitoring and prediction model for reactant and product concentrations.
  • To enable efficient kinetic analysis and reaction condition optimization in flow chemistry.

Main Methods:

  • Utilized online Fourier-transform infrared (FTIR) spectroscopy combined with dynamic flow rate control.
  • Constructed a quantification model using artificial neural networks based on spectroscopic data.
  • Performed continuous flow experiments with varying flow rates for kinetic analysis and optimization.

Main Results:

  • Successfully established a quantitative analysis method for continuous flow systems.
  • Demonstrated real-time monitoring and prediction of reactant and product concentrations.
  • Enabled rapid kinetic analysis and optimization of reaction conditions.

Conclusions:

  • The developed method provides an effective approach for real-time quantitative analysis in continuous flow reactions.
  • This technique significantly improves analytical efficiency for reaction monitoring and process optimization.
  • Offers a valuable tool for advancing the field of flow chemistry.