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Updated: Jun 26, 2026

Subsurface Defect Localization by Structured Heating Using Laser Projected Photothermal Thermography
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Published on: May 15, 2017

Deep Learning-Based OCT Segmentation for Stiffness Quantification in Evaluating Low-Level Laser Therapy for Wound

Gilang Titah Ramadhan1, Yih-Kuen Jan2, Ben-Yi Liau3

  • 1Department of Informatics, Tiga Serangkai University, Surakarta, Indonesia.

Journal of Biophotonics
|June 7, 2026
PubMed
Summary

Low-level laser therapy (LLLT) was found to reduce skin stiffness in wound tissue. This non-invasive treatment shows potential for modulating the biomechanical properties of healing wounds.

Keywords:
low‐level laser therapyskin injurysoft tissue stiffnesswound healing

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Area of Science:

  • Biomedical Engineering
  • Tissue Mechanics
  • Photobiomodulation

Background:

  • Assessing the short-term biomechanical response of wound tissue is crucial for understanding healing.
  • Skin stiffness serves as a key indicator of the tissue's immediate biomechanical state.
  • Low-level laser therapy (LLLT) is being investigated for its therapeutic effects on wound healing.

Purpose of the Study:

  • To evaluate the immediate biomechanical effects of LLLT on wound tissue.
  • To quantify changes in skin stiffness following LLLT application.
  • To explore LLLT's potential to modulate the wound's biomechanical environment.

Main Methods:

  • A 660 nm LLLT protocol was applied to wound sites.
  • Skin stiffness was measured using optical coherence tomography (OCT) with an air-jet indentation system.
  • A U-Net model automated OCT image segmentation for precise, layer-specific analysis.

Main Results:

  • The U-Net model achieved 92% segmentation accuracy, enabling reliable skin layer identification.
  • LLLT significantly decreased skin stiffness immediately after treatment.
  • This reduction indicates an acute modulation of tissue compliance by LLLT.

Conclusions:

  • Short-duration LLLT effectively reduces skin stiffness post-treatment.
  • LLLT demonstrates potential as a non-invasive method to alter the biomechanics of wound beds.
  • Further research can explore LLLT's role in optimizing wound healing through biomechanical modulation.