Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cellular Adaptation IV: Dysplasia and Metaplasia01:24

Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
Uterine Tubes01:16

Uterine Tubes

The uterine or fallopian tubes function as the conduit through which oocytes travel from the ovaries to the uterus. Each fallopian tube measures approximately 10 to 13 cm long and is anatomically divided into the infundibulum, ampulla, isthmus, and interstitial part (or intramural segment). The infundibulum is characterized by its funnel shape and features extensions called fimbriae which reach towards the peritoneal cavity. These fimbriae play a critical role during ovulation as they extend...
Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
Development of the Sexual Organs in the Embryo and Fetus01:15

Development of the Sexual Organs in the Embryo and Fetus

Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the male...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Low Expression of Cell Adhesion Molecule 1 in Resected Gastroenteropancreatic Neuroendocrine Tumors: Relationship With Lymph Node and Distant Metastasis.

Pathology international·2026
Same author

A Survey on Real-World Transurethral Surgery Procedures for Bladder Pain Syndrome and Interstitial Cystitis.

Lower urinary tract symptoms·2026
Same author

Evaluation of <i>NTRK</i> Fusions Detection Method in Esophageal Squamous Cell Carcinoma and Gastric Adenocarcinoma.

International journal of molecular sciences·2026
Same author

Effects of mitotically active polyploid giant cancer cells on chemoresistance through interaction with cancer-associated fibroblasts.

British journal of cancer·2025
Same author

Extracellular vesicles of cancer cells induce FOXP3+ fibroblasts and facilitate tumor invasion via the Wnt3-β-catenin pathway.

Oncogene·2025
Same author

Oncofetal IGF2BP3-mediated control of microRNA structural diversity in the malignancy of early-stage lung adenocarcinoma.

Proceedings of the National Academy of Sciences of the United States of America·2024

Related Experiment Video

Updated: Jun 9, 2026

An Efficient Method for Extracting Human Fallopian Tube Epithelia for Single-cell Analyses
07:03

An Efficient Method for Extracting Human Fallopian Tube Epithelia for Single-cell Analyses

Published on: March 28, 2025

Tubal epithelial alterations: evolving concepts.

Kei Koyama1, Daichi Maeda2,3, Akiteru Goto4

  • 1Department of Cellular and Organ Pathology, Graduate School of Medicine, Akita University, Akita, Japan. kkoyama@gipc.akita-u.ac.jp.

Journal of Gynecologic Oncology
|June 7, 2026
PubMed
Summary
This summary is machine-generated.

The fallopian tube harbors diverse precancerous lesions, including secretory cell outgrowth (SCOUT) and serous tubal intraepithelial carcinoma (STIC). These alterations show complex origins and varying risks, challenging linear progression models for ovarian cancer development.

Keywords:
Beta CateninFallopian TubesTumor Suppressor Protein p53

More Related Videos

Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection
08:09

Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection

Published on: July 25, 2017

Human Ovarian Surface Epithelium Organoids as a Platform to Study Tissue Regeneration
07:37

Human Ovarian Surface Epithelium Organoids as a Platform to Study Tissue Regeneration

Published on: August 16, 2024

Related Experiment Videos

Last Updated: Jun 9, 2026

An Efficient Method for Extracting Human Fallopian Tube Epithelia for Single-cell Analyses
07:03

An Efficient Method for Extracting Human Fallopian Tube Epithelia for Single-cell Analyses

Published on: March 28, 2025

Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection
08:09

Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection

Published on: July 25, 2017

Human Ovarian Surface Epithelium Organoids as a Platform to Study Tissue Regeneration
07:37

Human Ovarian Surface Epithelium Organoids as a Platform to Study Tissue Regeneration

Published on: August 16, 2024

Area of Science:

  • Gynecologic pathology
  • Ovarian cancer pathogenesis
  • Tubal epithelial alterations

Background:

  • The fallopian tube is increasingly recognized as a primary site for ovarian cancer development, especially high-grade serous carcinoma (HGSC).
  • Histopathological and molecular studies reveal a spectrum of tubal epithelial changes with diverse malignant potentials.

Purpose of the Study:

  • To review key tubal epithelial lesions and their potential roles in gynecologic carcinogenesis.
  • To discuss the evolving understanding of lesion progression and malignant potential.

Main Methods:

  • Review of histopathological and molecular analyses of fallopian tube lesions.
  • Integration of findings on specific lesions like SCOUT, p53 signature, STIL, STIC, β-catenin signatures, endometrioid tubal intraepithelial neoplasia, and PTH.

Main Results:

  • Lesions such as p53 signature, STIL, and STIC arise from secretory cells with TP53 alterations but may not follow a linear progression to HGSC.
  • SCOUTs, particularly Type II, are implicated as precursors to endometrioid carcinoma, though this cancer is rare.
  • Papillary tubal hyperplasia (PTH) shows potential overlap with low-grade serous carcinoma, challenging its traditional reactive classification.

Conclusions:

  • Tubal epithelial alterations are complex and heterogeneous, not fitting a simple linear model of tumorigenesis.
  • Accurate assessment of malignant potential requires integrating morphological, molecular, and spatial data.
  • Further research is crucial for understanding tubal pathology's role in gynecologic cancer.